Clinical and Practical Psychopharmacology
Clinical and Practical Psychopharmacology
Antidepressants, Mood Stabilizers, Antipsychotics, and the Risk of Cataract
January 29, 2019
Some studies have indicated that drugs used to treat depression might increase the risk of cataract. This installment of Clinical and Practical Psychopharmacology takes a closer look at the…
Clinical and Practical Psychopharmacology
How to Read a Research Paper: An Exercise in Critical Thinking
December 11, 2018
Tamsulosin, used to treat benign prostatic hyperplasia, was associated in a recent study with an increase in the risk of incident dementia. In this installment of his column, Dr…
Clinical and Practical Psychopharmacology
Statins as Antipsychotic Augmentation in Schizophrenia
September 25, 2018
Two recent meta-analyses examined an intriguing possibility: the usefulness of statins as antipsychotic augmentation. In this installment of Clinical and Practical Psychopharmacology, Dr Andrade takes a critical look at…
Clinical and Practical Psychopharmacology
Statins as Antipsychotic Augmentation in Schizophrenia
September 25, 2018
Two recent meta-analyses examined an intriguing possibility: the usefulness of statins as antipsychotic augmentation. In this installment of Clinical and Practical Psychopharmacology, Dr Andrade takes a critical look at…
Clinical and Practical Psychopharmacology
Adverse Pregnancy Outcomes Associated With Antiepileptic Drugs
July 31, 2018
Besides congenital malformation, what other risks might be associated with antiepileptic drugs during pregnancy? In this article, Dr Andrade discusses the results of a recent network meta-analysis evaluating outcomes…
Clinical and Practical Psychopharmacology
Congenital Malformations Associated With Antiepileptic Drugs
July 17, 2018
Which antiepileptic drugs present the greatest risks during pregnancy? In this installment of Clinical and Practical Psychopharmacology, Dr Andrade looks at the evidence to determine the drugs associated with…
Clinical and Practical Psychopharmacology
Sedative Hypnotics and the Risk of Falls and Fractures in the Elderly
May 22, 2018
Older age, poor sleep, and the use of the "Z" sedative hypnotic drugs (eg, zolpidem) commonly go together. In this Clinical and Practical Psychopharmacology article, Dr Andrade discusses the…
Clinical and Practical Psychopharmacology
Commentary on a Network Meta-Analysis of Antidepressant Efficacy and Acceptability
April 25, 2018
Nine years ago, a network meta-analysis ranked the efficacy and acceptability of 12 newer antidepressants in adults with MDD; the analysis was recently updated to reflect new drugs. In…
Clinical and Practical Psychopharmacology
Ketamine for Depression, Part 6
March 27, 2018
One of the most important potential applications for ketamine in subanesthetic doses is as a crisis intervention treatment to reduce suicidal ideation. In this Clinical and Practical Psychopharmacology article,…
Clinical and Practical Psychopharmacology
Adverse Gestational Outcomes Associated With ADHD Medication Exposure During Pregnancy
February 21, 2018
ADHD medication use during pregnancy has increased in recent years. In this article, Dr Andrade reviews recent evidence on whether amphetamines, methylphenidate, and atomoxetine exposure in early and late…
Clinical and Practical Psychopharmacology
Risk of Major Congenital Malformations With Methylphenidate or Amphetamine Use
January 23, 2018
How safe is it for pregnant women to use ADHD medication? Dr Andrade reviews recent studies on methylphenidate and amphetamine use during pregnancy to evaluate the findings and weigh…
Clinical and Practical Psychopharmacology
Memantine as an Augmentation Treatment for Schizophrenia
November 21, 2017
In this month’s Clinical and Practical Psychopharmacology column, Dr Andrade takes a close look at trials investigating the efficacy of memantine in treating schizophrenia, and discusses why it may…
Clinical and Practical Psychopharmacology
Antidepressant Exposure During Pregnancy and Risk of Autism, 2
October 25, 2017
This installment of the Clinical and Practical Psychopharmacology column continues looking at the evidence regarding autism and use of antidepressants during pregnancy. Dr Andrade discusses whether 5 new studies…
Clinical and Practical Psychopharmacology
Antidepressant Exposure During Pregnancy and Risk of Autism, 1
September 26, 2017
In this installment of his Clinical and Practical Psychopharmacology column, Dr Andrade provides a meta-review of 6 meta-analyses examining the risk of autism spectrum disorder associated with use of…
Clinical and Practical Psychopharmacology
Ketamine for Depression, 5: Pharmacokinetic and Pharmacodynamic Drug Interactions
August 23, 2017
This installment of Dr Andrade’s series on the use of ketamine for depression considers possible interactions of ketamine with other medications—both what we know and what we don’ t…
Clinical and Practical Psychopharmacology
Ketamine for Depression, 3: Does Chirality Matter?
June 28, 2017
Ketamine is a racemic mixture of R- and S-enantiomers, and S-ketamine has greater analgesic and anesthetic action than R-ketamine. In this month’s Clinical and Practical Psychopharmacology column, Dr Andrade…
Clinical and Practical Psychopharmacology
Ketamine for Depression, 2: Diagnostic and Contextual Indications
May 24, 2017
In this article, Dr Andrade looks at the diagnostic indications for use of ketamine as an antidepressant, as well as specific clinical situations in which ketamine may be particularly…
Clinical and Practical Psychopharmacology
Ketamine for Depression, 1: Efficacy, Adverse Effects, and Mechanism of Action
April 26, 2017
In this issue of Clinical and Practical Psychopharmacology, Dr Andrade outlines clinical aspects of ketamine, an anesthetic drug that, at subanesthetic doses, has demonstrated rapid response in even treatment-resistant…
