Original Research

JCP
ECT for Psychotic vs Nonpsychotic Depression
Original Research

January 29, 2025

Patients with major depression with psychotic features had higher response rates to ECT than those without psychotic features and similar rates of adverse cognitive effects. After adjustment for confounders,...
, , , et al
PCC
COVID’s Mental Health Impact on Primary Care Health Workers
Original Research

January 28, 2025

This study assessed the prevalence of anxiety, depression, insomnia, and perceived stress, as well as the factors that mediate stress with depression and anxiety, among rural health care workers.
, , , et al
JCP
Esketamine Nasal Spray vs Quetiapine ER in Treatment-Resistant Depression
Original Research

January 27, 2025

Esketamine was associated with significantly larger improvements in work productivity loss and related costs compared to quetiapine, suggesting greater benefits from patient well-being and employer perspectives.
, , , et al
JCP
Psychological Challenges of Adults with SMI during the COVID-19 Pandemic
Original Research

January 22, 2025

Adults with SMI diagnosed with COVID-19 and those who sheltered in place during lockdown experienced more severe psychological distress compared to those not diagnosed with COVID-19.
, , , et al
JCP
Sulforaphane Added to Antipsychotics for Negative Symptoms of Schizophrenia
Original Research

January 20, 2025

Add-on high dose sulforaphane may reduce negative symptoms in patients with schizophrenia, although the clinical significance of this reduction needs further evaluation.
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PCC
Impact of Lemborexant on Daytime Functioning
Original Research

January 16, 2025

Improved insomnia symptoms with lemborexant treatment may translate into improved daytime functioning.
, , , et al
PCC
Suicide-Specific Cognitions in US Military Veterans
Original Research

January 14, 2025

This study examined data from a large, nationally representative sample of US veterans to determine the prevalence and correlates of high chronic suicide risk.
, , , et al
JCP
BI 1358894 in Borderline Personality Disorder
Original Research

January 13, 2025

Although the primary endpoint was not met, BI 1358894 was well-tolerated with no increase in self-harm or suicidality.
, , , et al
JCP
Cardiovascular Risk Factors and Second Generation Antipsychotics
Original Research

January 8, 2025

Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental illness who use antipsychotics are common and frequently untreated.
, , , et al
JCP
IV Hydroxyzine vs Haloperidol for Delirium
Original Research

January 6, 2025

Hydroxyzine showed a significantly higher rate of delirium improvement than haloperidol, with no significant difference in the time to improvement.
, , , et al
JCP
Olanzapine/Samidorphan Effects on Weight Gain
Original Research

January 2, 2025

Treatment with a combination of olanzapine and samidorphan was associated with less weight gain and reduced risk of reaching ≥7% or ≥10% gain in body weight versus olanzapine over...
, , , et al
JCP
Substance and Opioid Use Disorders Among IBD Hospitalizations
Original Research

January 2, 2025

A higher prevalence of SUD and opioid use disorder was found among hospitalizations for inflammatory bowel disease, and these elevated prevalences were linked to distinct demographic, socioeconomic, and geographic...
, , , et al
JCP
Treatments and Treatment Predictors in Patients With SUDs and ADHD
Original Research

December 23, 2024

Treatment site explained more of the variation in ADHD treatment provision than patient factors. Higher ADHD symptom severity and sobriety at intake were associated with receiving ADHD treatment.
, , , et al
PCC
Evolution of Treatment Modalities for PTSD
Original Research

December 12, 2024

The authors provide a bibliometric analysis of the most-cited articles published from 1990 to 2020 on evidence-based treatment modalities for PTSD to highlight significant developments in its understanding and management.
, , , et al
JCP
Long-Term Safety and Treatment Effect of Olanzapine/Samidorphan
Original Research

December 4, 2024

During up to 4 years of treatment, the combination of olanzapine/samidorphan was safe and well-tolerated, and patients’ symptoms remained stable.
, , , et al
JCP
Sex Differences in Antidepressant Acceptability
Original Research

December 4, 2024

This study provides evidence of sex differences in antidepressant acceptability, with fluoxetine more acceptable for men than women and the reverse true for paroxetine. Findings suggest the importance of...
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PCC
Intervention to Enhance Mental Health Competency
Original Research

December 3, 2024

This study evaluated a novel curriculum aimed to increase non-psychiatry providers’ confidence in treating mental health conditions.
, , , et al
JCP
PTSD and Risk of Suicide Reattempt
Original Research

November 25, 2024

After controlling for comorbid psychiatric conditions and other variables, PTSD was associated with suicide reattempt at 6 months (OR= 2.33) and with rehospitalization in psychiatric settings (OR=2.24) and nonpsychiatric...
, , , et al
JCP
MDD and Bipolar Disorder in Black and White Postpartum Women
Original Research

November 20, 2024

No significant difference was observed in the rate of postpartum MDD in Black (40%) versus white (35%) women. However, bipolar disorder significantly differed between Black (19.2%) and white (11.5%)...
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JCP
Hyperbaric Oxygen Therapy for Combat-Associated PTSD
Original Research

November 10, 2024

Hyperbaric oxygen therapy demonstrated significant improvements on measures of depression in male veterans with combat-associated PTSD.
, , , et al
PCC
Psychiatric Comorbidities in Adolescents With Polycystic Ovary Syndrome
Original Research

November 7, 2024

PCOS symptoms extend beyond reproductive issues, with noted correlations to anxiety, depression, and suicidal attempts. This study assessed psychiatric comorbidities among hospitalized adolescent females with PCOS.
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JCP
Mixed Features and Suicide Risk in Individuals With Major Depressive Episode
Original Research

November 6, 2024

In a large sample of the French population, mixed features were linked to a higher risk of suicide attempts in patients with a major depressive episode.
, , , et al
JCP
History of Concussion and Maternal Mental Illness Risk
Original Research

November 4, 2024

Individuals with a history of concussion had an increased risk of severe maternal mental illness; the association was strongest in those with no history of mental illness.
, , , et al
JCP
Opioid Use Disorder Treatment in Sexually and Gender Diverse Patients
Original Research

October 30, 2024

The disparities in buprenorphine prescriptions and in outpatient medical visit access between sexually and gender diverse (SGD) and non-SGD cohorts found in this study highlight priorities for culturally responsive...
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