Original Research
Original Research
Autoimmune Diseases, Treatments, and Dementia Risk: A Population-Based Case-Control Study from Taiwan
October 15, 2025
Thirteen autoimmune diseases were linked with an elevated dementia risk, particularly Behçet's disease, multiple sclerosis, and lupus. Associations with vascular dementia were stronger than with Alzheimer's disease.
Original Research
Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
October 13, 2025
This pilot trial suggests that brexpiprazole might be beneficial in reducing substance craving and use and improve quality of life in this difficult-to-treat patient population.
Original Research
Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults with Bipolar II Depression
September 29, 2025
There was no significant difference in suicidal ideation in those receiving IPSRT plus placebo vs IPSRT plus quetiapine. IPSRT has the potential to mitigate suicidal ideation in patients with...
Original Research
Aripiprazole or Bupropion Augmentation vs Switching to Bupropion in Treatment Resistant Depression
September 22, 2025
In this model, augmentation with bupropion better balanced efficacy and tolerability in TRD in adults under 85 than did switching to bupropion or augmentation with aripiprazole. Augmentation with aripiprazole...
Original Research
Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review
September 22, 2025
In this naturalistic sample of patients with similarly severe treatment resistant depression treated over a 4- to 5-week induction period, intravenous racemic ketamine was associated with more rapid response...
Original Research
Relationships between Prenatal Body Composition and Mental Health Are Moderated by Physical Activity and Diet
September 15, 2025
Higher body fat mass during pregnancy is associated with more depression and anxiety symptoms. However, physical activity and adherence to high-quality diets can lessen these effects.
Original Research
Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study
September 11, 2025
Older adults were found to have less depression and anxiety compared to middle-aged adults; loneliness and perception of knowledge about COVID can affect the association between the presence of...
Original Research
Validity of an Online ADHD Assessment in a Real-World Sample of Adults Seeking Web-Based Mental Healthcare
September 8, 2025
The online assessment correctly identified over 80% of ADHD-positive cases. Compared with the clinical interview, the online assessment was more conservative in rendering ADHD-positive diagnoses.
Original Research
Effects of the October 7, 2023, Terrorist Attack on PTSD, Depression, Anxiety, and Suicidal Ideation Across Distinct Exposure Groups
September 3, 2025
Prevalence and severity of psychiatric symptoms declined between 1 month and 1 year following the attack; exposure group moderated these changes. Reserve-duty combatants had the highest rates of probable...
Original Research
Comparing the Cognitive Effects of Repeated IV Ketamine and ECT in Patients with Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial
September 3, 2025
Patients treated with ketamine demonstrated superior cognitive functioning compared with those treated with ECT following a 3-week treatment course. No differences between treatments were observed among responders in at...
Original Research
Five-Year Outcomes of First Suicide Attempts: Lethality, Recurrence, and Mortality
September 1, 2025
Recurrence of suicide attempt occurred in 37.2% of patients, with 27.8% having ≥3 attempts. Alcohol use predicted high-lethality first attempts, and female sex predicted multiple reattempts.
Original Research
Artificial Intelligence in Depression – Medication Enhancement (AID-ME): A Cluster Randomized Trial of a Clinical Decision Support System for Personalized Depression Treatment Selection and Management
August 27, 2025
This study provides preliminary evidence that longitudinal use of an AI-enabled clinical decision support system can improve outcomes in MDD.
