Original Research
Original Research
CAN-BIND-1 Outcomes and Early Response Prediction in MDD
February 5, 2019
Antidepressant medications are often prescribed with little certainty about their potential effectiveness in individual patients. Can early symptom reduction help predict later symptomatic and functional outcomes of antidepressant treatment?...
Original Research
Psychotic Features in Patients With MDD
January 15, 2019
Psychotic features within major depressive disorder (MDD) are associated with poor treatment outcome. This article explores whether sociodemographic and clinical characteristics of and pharmacologic treatments received by patients with...
Original Research
Long-Term Remission With Cariprazine in Patients With Schizophrenia
January 8, 2019
When treating patients with schizophrenia, achieving stable, long-term remission is an important step toward the goal of functional recovery. This study evaluated the effect of cariprazine on several measures...
Original Research
Cost-Effectiveness of "Next-Step" Depression Treatment Strategies
December 18, 2018
Aripiprazole is commonly prescribed as a next-step pharmacotherapy for treatment-resistant depression, but its cost-effectiveness as an adjunct to antidepressants is unknown. Read this article to learn how the cost-effectiveness...
Original Research
Valbenazine for Tardive Dyskinesia: Results From the KINECT 3 Study
December 18, 2018
Could valbenazine help your patients who experience antipsychotic-induced abnormal movements? This follow-up analysis of a phase 3 study provides further insights into the efficacy of valbenazine for tardive dyskinesia...
Original Research
Caregiver Burden in PANS
December 11, 2018
Pediatric acute-onset neuropsychiatric disorder (PANS) is characterized by abrupt onset of obsessive-compulsive disorder and/or food restriction with 2 or more similarly debilitating neuropsychiatric symptoms. Read this article to learn...
Original Research
Adjunctive Anti-Inflammatory Treatments for Bipolar Depression
December 4, 2018
Nonsteroidal anti-inflammatory drugs (NSAIDs) and antioxidative treatments have shown antidepressant potential as adjunct treatments. Read this article to learn if adjunctive treatment with the antioxidative agent N-acetylcysteine, the NSAID...
Original Research
Sudden Improvement in Symptoms During Antidepressant Clinical Trials
December 4, 2018
If a patient's depressive symptoms subside very quickly after antidepressant treatment is initiated, do those gains represent a true and lasting response? This study examined whether sudden improvement in...
Original Research
Depression, Cognition, and Functional Impairment
November 13, 2018
Depression is strongly associated with functional impairment. Some hypothesize that cognitive dysfunction, which is also often associated with depression, might mediate the impact of depression on functioning. This study...
Original Research
Impact of Frailty on Behavioral and Psychological Symptoms of Dementia and Caregiver Burden
November 13, 2018
Frailty is associated with negative health outcomes in dementia patients, but could it also predict more psychological symptoms and greater caregiver burden? This study of 1,193 Alzheimer's disease patients...
Original Research
Cerebral Blood Flow After Late-Life Depression Treatment
October 23, 2018
Could cerebrovascular disease be a factor in your elderly patient's depression? This article investigated the association of white matter hyperintensities and cerebral blood flow with late-life depressive symptoms and...
