More About Emerging Approaches in Schizophrenia
Review Article
Cognitive Effects of ECT in Schizophrenia: A Review
June 5, 2024
ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
Original Research
Effect of Lurasidone on Social Functioning
January 31, 2024
Impaired social functioning in schizophrenia affects personal recovery. This analysis looked at the effects of lurasidone on social functioning in schizophrenia during a double-blind, placebo-controlled study and subsequent open-label…
Narrative Review
Alternative Treatment for Agitation in Schizophrenia and Bipolar Disorder
January 30, 2024
While oral and intramuscular formulations of pharmacologic agents continue to be commonly used to treat acute agitation, novel agents with alternative routes of delivery are becoming available.
Original Research
Earlier Use of Paliperidone Palmitate in Patients With Schizophrenia
September 25, 2023
Long-acting injectable antipsychotics (LAIs) are typically reserved for patients with a long history of schizophrenia. This analysis of 3 studies found benefit in initiating the LAI paliperidone palmitate earlier…
Original Research
Safety and Efficacy of Aripiprazole 2-Month Ready-to-Use 960 mg
September 4, 2023
A new formulation of injectable aripiprazole for administration every 2 months showed similar rates of treatment-emergent adverse events to aripiprazole once-monthly 400 mg. Patients in both groups remained clinically…
Original Research
Generalizability of RCTs in First-Episode Schizophrenia
March 29, 2023
First-episode schizophrenia patients with suicidal ideation and substance use disorder are often excluded from clinical trials. Omitting them does not affect key outcome measures but excludes many potential subjects.
Original Research
Olanzapine/Samidorphan Mitigates Weight Gain in Early Illness
March 22, 2023
In patients with early-phase schizophrenia or bipolar disorder, combination olanzapine and samidorphan resulted in less weight gain at week 12 than olanzapine alone. Antipsychotic efficacy was similar between the…
