Focus on Psychosis

Recently published articles about Focus on Psychosis

JCP
Cardiovascular Risk Factors and Second Generation Antipsychotics
Original Research

January 8, 2025

Despite well-documented cardiovascular disease (CVD) morbidity and mortality, CVD risks among people with severe mental illness who use antipsychotics are common and frequently untreated.
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JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
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JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
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JCP
Emotional Neglect and Inflammatory Ratios in First-Episode Psychosis
Original Research

May 22, 2024

The authors examined the link between the immune system and childhood traumatic events in patients with first-episode psychosis.
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JCP
Concomitant LAIs and Time to Rehospitalization in Patients Receiving Clozapine
Original Research

May 1, 2024

Clozapine plus LAI antipsychotics was associated with lower risk of rehospitalization compared to both clozapine plus oral antipsychotics and clozapine monotherapy.
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JCP
Clozapine Use and Specific Indications
Original Research

April 29, 2024

Clozapine initiation is uncommon in people with psychotic disorders who have experienced events suggesting clozapine is indicated, with even lower rates in Black and Hispanic patients.
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Recent JCP Articles on Focus on Psychosis

JCP
Antipsychotic Dose and Weight Gain
Meta-Analysis

February 8, 2023

Although effects on weight gain have been explored for several antipsychotics, the role of dose in producing these effects has not been widely studied. This meta-analysis examined the association...
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JCP
Telehealth of CSC in Early Psychosis During COVID-19
Original Research

November 30, 2022

As the COVID-19 pandemic emerged in 2020, access to in-person clinical care was restricted. This study explored if transition of coordinated specialty care to telehealth for psychosis patients allowed...
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JCP
Economic Burden of Schizophrenia in the US
Original Research

October 10, 2022

Schizophrenia is associated with significant economic burden, not only for patients but also for families, other caregivers, and the wider society. This study analyzed recent data and literature to...
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Featured Focus on Psychosis Research

JCP
Add-on Pramipexole for Schizophrenia
Original Research

August 1, 2022

Several small clinical trials have reported that the dopamine agonist pramipexole was beneficial in treating patients with schizophrenia. This 16-week, multicenter, double-blind, randomized, placebo-controlled study was conducted to test...
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JCP
Effects of a Digital Medicine System on Psychiatric Hospitalization Rates for Adults With Schizophrenia
Original Research

April 11, 2022

This clinical trial investigated whether hospitalization rates improved when patients with schizophrenia were treated via a digital medicine system (aripiprazole tablets with sensor) versus oral standard-of-care therapy.
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JCP
Association of Higher ALFF and Suicidal Ideation in BD
Original Research

March 30, 2022

Higher amplitude of low frequency fluctuation in the right hippocampus and thalamus has been found to be associated with suicidal ideation in major depressive disorder. The present study evaluated...
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JCP
Severity of Antipsychotic-Induced Cervical Dystonia by Algorithm-Based Rating System
Original Research

April 15, 2024

Rater consensus data were compared with deviation angle data using AI-based deviation angle measurement technology. With the range of tilt angles found in the study, the authors propose a...
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JCP
Excess Mortality Associated With Schizophrenia
Original Research

September 13, 2023

Females, patients with connective tissue disorders, and those aged 20 years or younger were especially impacted by the effect of schizophrenia on increasing mortality.
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JCP
Inflammatory Features in Prodromal Psychosis
Original Research

July 17, 2023

This study suggests that niacin response tests should be considered in early psychosis identification and prediction.
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JCP
Generalizability of RCTs in First-Episode Schizophrenia
Original Research

March 29, 2023

First-episode schizophrenia patients with suicidal ideation and substance use disorder are often excluded from clinical trials. Omitting them does not affect key outcome measures but excludes many potential subjects.
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JCP
Neighborhood Vulnerability in First-Episode Psychosis
Original Research

March 13, 2023

Psychosocial difficulties in people with first-episode psychosis could be related to a lack of resources in the area where they live.
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JCP
Predictors for Initiation of LAIs in Individuals With Early-Phase Schizophrenia
Original Research

February 13, 2023

Initiation of LAIs was predicted by greater switching of oral antipsychotics and more ED visits. LAIs are often used to respond to relapse rather than prevent it.
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