The Journal of
Clinical Psychiatry

Volume 77 • 2016 • 12

Meta-Analysis

Glutamatergic Agents as Add-On Medication for the Treatment of Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

J Clin Psychiatry 2016;77(12):e1576-e1583

Zacharias G. Laoutidis, MD ; Georgia E. Lekka, MD ; Kanellos T. Kioulos, MD

Original Research

Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide: Results From the 2007-2012 National Health and Nutrition Examination Surveys

J Clin Psychiatry 2016;77(12):1666-1671

M. Soledad Cepeda, MD, PhD ; Paul Stang, PhD ; Rupa Makadia, MS

Original Research

Lurasidone Dose Escalation in Early Nonresponding Patients With Schizophrenia: A Randomized, Placebo-Controlled Study

J Clin Psychiatry 2016;77(12):1672-1680

Antony Loebel, MD ; Robert Silva, PhD ; Robert Goldman, PhD ; Kei Watabe, MS ; Josephine Cucchiaro, PhD ; Leslie Citrome, MD, MPH ; John M. Kane, MD

Original Research

Evidence to Support Montgomery-Asberg Depression Rating Scale Administration Every 24 Hours to Assess Rapid Onset of Treatment Response

J Clin Psychiatry 2016;77(12):1681-1686

Kristen M. Johnson, PhD, MPH ; Jacob M. Devine, MA ; Kai Fai Ho, PhD ; Kellee A. Howard, MA, MSc ; Todd L. Saretsky, MPH ; Carol A. Jamieson, BSc, FIBMS

Original Research

Efficacy and Safety of Vilazodone in Patients With Generalized Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Trial

J Clin Psychiatry 2016;77(12):1687-1694

Suresh Durgam, MD ; Carl Gommoll, MS ; Giovanna Forero, MA ; Rene Nunez, MD ; Xiongwen Tang, PhD ; Maju Mathews, MD ; David V. Sheehan, MD, MBA

Original Research

Adjunctive Brexpiprazole in Patients With Major Depressive Disorder and Irritability: An Exploratory Study

J Clin Psychiatry 2016;77(12):1695-1701

Maurizio Fava, MD ; François Ménard, MD ; Charlotte Kampp Davidsen, MSc ; Ross A. Baker, PhD, MBA

Original Research

Time Trends in Lifetime Incidence Rates of First-Time Diagnosed Bipolar and Depressive Disorders Across 16 Years in Danish Psychiatric Hospitals: A Nationwide Study

J Clin Psychiatry 2016;77(12):e1570-e1575

Christina Mohr Jensen, MSc ; Hans-Christoph Steinhausen, MD, PhD, DMSc

Original Research

Reducing Dropout in Treatment for Depression: Translating Dropout Predictors Into Individualized Treatment Recommendations

J Clin Psychiatry 2016;77(12):e1584-e1590

Sigal Zilcha-Mano, PhD ; John R. Keefe, MA ; Harold Chui, PhD ; Avinadav Rubin, MA ; Marna S. Barrett, PhD ; Jacques P. Barber, PhD

Original Research

A Randomized Trial of Dialectical Behavior Therapy in High-Risk Suicidal Veterans

J Clin Psychiatry 2016;77(12):e1591-e1600

Marianne Goodman, MD ; David Banthin, PhD ; Nicholas J. Blair, BA ; Kathryn A. Mascitelli, BA ; Jaime Wilsnack, MA ; Jennifer Chen, PsyD ; Julie W. Messenger, PhD ; M. Mercedes Perez-Rodriguez, MD ; Joseph Triebwasser, MD ; Harold W. Koenigsberg, MD ; Raymond R. Goetz, PhD ; Erin A. Hazlett, PhD ; Antonia S. New, MD

Original Research

Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison

J Clin Psychiatry 2016;77(12):e1601-e1609

Marco Pozzi, PhD^a,‡ ; Simone Pisano, PhD^b,‡ ; Silvana Bertella, MD^a ; Annalisa Capuano, PhD^c ; Renata Rizzo, PhD^d ; Stefania Antoniazzi, PharmD^e ; Fabiana Auricchio, PhD^c ; Carla Carnovale, PharmD^e ; Dario Cattaneo, PhD^e ; Carmen Ferrajolo, PhD^c ; Marta Gentili, PharmD^e ; Giuseppe Guastella, MD^f ; Elisa Mani, MD^a ; Concetta Rafaniello, PhD^c ; Maria Pia Riccio, MD^b ; Maria Grazia Scuderi, MD^d ; Serena Sperandeo, MD^b ; Liberata Sportiello, PhD^c ; Laura Villa, MD^a ; Sonia Radice, BiolD^e ; Emilio Clementi, PhD^a,g, ; Francesco Rossi, MD^c ; Antonio Pascotto, MD^b ; Renato Bernardini, MD^f ; Massimo Molteni, MD^a,§ ; Carmela Bravaccio, PhD^h,§

Original Research

Adjunctive Taurine in First-Episode Psychosis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study

J Clin Psychiatry 2016;77(12):e1610-e1617

Colin P. O'Donnell, MB BCh, MSc, MRCPsych^a,* ; Kelly A. Allott, DPsych^d,e ; Brendan P. Murphy, MD^b,c ; Hok Pan Yuen, MSc^d,e ; Tina-Marie Proffitt, DPsych^d,e ; Alicia Papas, DPsych^d ; Jennifer Moral, DPsych^d ; Tee Pham, DPsychd ; Michaela K. O'Regan, DPsych^d ; Christina Phassouliotis, DPsych^d ; Raelene Simpson, PhD^d ; Patrick D. McGorry, MD, PhD^d,e

Original Research

Generalizability of Neuroimaging Studies in 5 Common Psychiatric Disorders Based on the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

J Clin Psychiatry 2016;77(12):e1618-e1625

Carlos Blanco, MD, PhD ; Melanie M. Wall, PhD ; Martin A. Lindquist, PhD ; Jorge Mario Rodríguez-Fernández, MD ; Silvia Franco, MD ; Shuai Wang, PhD ; Mark Olfson, MD, MPH

Original Research

A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer

J Clin Psychiatry 2016;77(12):e1626-e1630

Daniel W. Bradford, MD, MPH ; Joseph Goulet, PhD ; Marcia Hunt, PhD ; Natasha C. Cunningham, MD ; Rani Hoff, PhD

Original Research

Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer's Disease

J Clin Psychiatry 2016;77(12):e1631-e1638

Enrica Cavedo, PhD ; Bruno Dubois, MD ; Olivier Colliot, PhD ; Simone Lista, PhD ; Bernard Croisile, MD ; Guy Louis Tisserand, MD ; Jacques Touchon, MD ; Alain Bonafe, MD ; Pierre J. Ousset, MD ; Olivier Rouaud, MD ; Fréderic Ricolfi, MD ; Alain Vighetto, MD ; Florence Pasquier, MD ; Samantha Galluzzi, MD ; Christine Delmaire, MD ; Mathieu Ceccaldi, MD ; Nadine Girard, MD ; Stéphane Lehericy, MD ; Françoise Duveau, MD ; Marie Chupin, PhD ; Marie Sarazin, MD ; Didier Dormont, MD ; Harald Hampel, MD, PhD

Original Research

Targeting Treatments to Improve Cognitive Function in Mood Disorder: Suggestions From Trials Using Erythropoietin

J Clin Psychiatry 2016;77(12):e1639-e1646

Kamilla Woznica Miskowiak, MSc, PhD ; A. John Rush, Jr, MD ; Thomas A. Gerds, PhD ; Maj Vinberg, MD, PhD ; Lars V. Kessing, MD

Article

Introduction: Focus on Geriatric Psychiatry December 2016

J Clin Psychiatry 2016;77(12):1702-1703

Helen Lavretsky, MD, MS

Article

Psychotherapy for Depression in Older Veterans Via Telemedicine: Effect on Quality of Life, Satisfaction, Treatment Credibility, and Service Delivery Perception

J Clin Psychiatry 2016;77(12):1704-1711

Leonard E. Egede, MD, MS ; Ron Acierno, PhD ; Rebecca G. Knapp, PhD ; Rebekah J. Walker, PhD ; Elizabeth H. Payne, PhD ; B. Christopher Frueh, PhD

Article

Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database

J Clin Psychiatry 2016;77(12):1712-1718

Alessandra Marengoni, MD, PhD ; Graziano Onder, MD, PhD ; Luca Degli Esposti, EconD ; Pierluigi Russo, MD, PhD ; Diego Sangiorgi, MStat ; Stefano Buda, ElEng ; Massimo Fini, MD ; Niccolò Marchionni, MD ; Stefano Bonassi, PhD ; Federica Mammarella, MD ; Walter Marrocco, MD ; Giuseppe Pozzi, MD ; Katie Palmer, PhD ; Alessandro Monaco, PhD ; Sergio Pecorelli, MD, PhD ; Luca Pani, MD

Article

Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study

J Clin Psychiatry 2016;77(12):e1549-e1556

Caterina Trevisan, MD ; Nicola Veronese, MD ; Francesco Bolzetta, MD ; Marina De Rui, MD ; Christoph U. Correll, MD ; Sabina Zambon, MD ; Estella Musacchio, MD ; Leonardo Sartori, MD ; Egle Perissinotto, ScD ; Gaetano Crepaldi, MD ; Marco Solmi, MD ; Enzo Manzato, MD ; Giuseppe Sergi, MD

Article

Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia

J Clin Psychiatry 2016;77(12):e1557-e1563

Yusuke Iwata, MD ; Shinichiro Nakajima, MD, PhD ; Fernando Caravaggio, BSc, PhD ; Takefumi Suzuki, MD, PhD ; Hiroyuki Uchida, MD, PhD ; Eric Plitman, BSc ; Jun Ku Chung, BSc ; Wanna Mar, MA ; Philip Gerretsen, MSW, MD, PhD ; Bruce G. Pollock, MD, PhD ; Benoit H. Mulsant, MD, MS ; Tarek K. Rajji, MD ; David C. Mamo, MD ; Ariel Graff-Guerrero, MD, PhD

Article

Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer's Disease

J Clin Psychiatry 2016;77(12):e1564-e1569

Elise A. Weamer, MPH ; Mary Ann A. DeMichele-Sweet, PhD ; Yona K. Cloonan, PhD ; Oscar L. Lopez, MD ; Robert A. Sweet, MD

Commentary

A Radical Proposal to Address the Problem of the Lack of Generalizability of Placebo-Controlled Studies of Antidepressants

J Clin Psychiatry 2016;77(12):e1647-e1649

Mark Zimmerman, MD

Clinical and Practical Psychopharmacology

Antipsychotic Drugs in Schizophrenia: Relative Effects in Patients With and Without Treatment Resistance

J Clin Psychiatry 2016;77(12):e1656-e1660

Chittaranjan Andrade, MD

Letter to the Editor

The Need to Assess Suicidal Risk in the Checklist for Prescribing Opioids

J Clin Psychiatry 2016;77(12):1719

Emilie Olié, MD, PhD ; Philippe Courtet, MD, PhD

Letter to the Editor

Clinical Correlates of Oral Glucose Tolerance Test Performance in Olanzapine-Treated Patients with Schizophrenia or Schizoaffective Disorder

J Clin Psychiatry 2016;77(12):e1650-e1651

Jeffrey Guina, MD ; Ankur Gupta, MD ; Daniel D. Langleben, MD ; Igor Elman, MD

Letter to the Editor

Considering the Complexity of Treatment Response in Psychiatric Clinical Trials

J Clin Psychiatry 2016;77(12):e1652

Juliana Belo Diniz, MD, PhD ; Roseli Gedanke Shavitt, MD, PhD ; Eurípedes Constantino Miguel, MD, PhD ; Daniel L. C. Costa, MD

Letter to the Editor

Antibiotics or Infection Itself? The Possible Importance of Inflammatory Cytokines on Mental States

J Clin Psychiatry 2016;77(12):e1653

Wakako Ishii, MD ; Shihoko Komine-Aizawa, MD, PhD ; Satoshi Hayakawa, MD, PhD

Letter to the Editor

Dr Lurie and Colleagues Reply

J Clin Psychiatry 2016;77(12):e1654

Ido Lurie, MD ; Yu-Xiao Yang, MD, MSCE ; Kevin Haynes, PharmD, MSCE ; Ronac Mamtani, MD, MSC ; Ben Boursi, MD

Letter to the Editor

Correction: Nocturnal Wakefulness Is Associated With Next-Day Suicidal Ideation in Major Depressive Disorder and Bipolar Disorder

J Clin Psychiatry 2016;77(12):e1655

Volume 77 • 2016 • 12

Meta-Analysis

Glutamatergic Agents as Add-On Medication for the Treatment of Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Original Research

Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide: Results From the 2007-2012 National Health and Nutrition Examination Surveys

Lurasidone Dose Escalation in Early Nonresponding Patients With Schizophrenia: A Randomized, Placebo-Controlled Study

Evidence to Support Montgomery-Asberg Depression Rating Scale Administration Every 24 Hours to Assess Rapid Onset of Treatment Response

Efficacy and Safety of Vilazodone in Patients With Generalized Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Trial

Adjunctive Brexpiprazole in Patients With Major Depressive Disorder and Irritability: An Exploratory Study

Time Trends in Lifetime Incidence Rates of First-Time Diagnosed Bipolar and Depressive Disorders Across 16 Years in Danish Psychiatric Hospitals: A Nationwide Study

Reducing Dropout in Treatment for Depression: Translating Dropout Predictors Into Individualized Treatment Recommendations

A Randomized Trial of Dialectical Behavior Therapy in High-Risk Suicidal Veterans

Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison

Adjunctive Taurine in First-Episode Psychosis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study

Generalizability of Neuroimaging Studies in 5 Common Psychiatric Disorders Based on the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer

Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer's Disease

Targeting Treatments to Improve Cognitive Function in Mood Disorder: Suggestions From Trials Using Erythropoietin

Article

Introduction: Focus on Geriatric Psychiatry December 2016

Psychotherapy for Depression in Older Veterans Via Telemedicine: Effect on Quality of Life, Satisfaction, Treatment Credibility, and Service Delivery Perception

Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database

Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study

Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia

Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer's Disease

Commentary

A Radical Proposal to Address the Problem of the Lack of Generalizability of Placebo-Controlled Studies of Antidepressants

Clinical and Practical Psychopharmacology

Antipsychotic Drugs in Schizophrenia: Relative Effects in Patients With and Without Treatment Resistance

Letter to the Editor

The Need to Assess Suicidal Risk in the Checklist for Prescribing Opioids

Clinical Correlates of Oral Glucose Tolerance Test Performance in Olanzapine-Treated Patients with Schizophrenia or Schizoaffective Disorder

Considering the Complexity of Treatment Response in Psychiatric Clinical Trials

Antibiotics or Infection Itself? The Possible Importance of Inflammatory Cytokines on Mental States

Dr Lurie and Colleagues Reply

Correction: Nocturnal Wakefulness Is Associated With Next-Day Suicidal Ideation in Major Depressive Disorder and Bipolar Disorder

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Volume 77 • 2016 • 12

Meta-Analysis

Glutamatergic Agents as Add-On Medication for the Treatment of Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Original Research

Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide: Results From the 2007-2012 National Health and Nutrition Examination Surveys

Lurasidone Dose Escalation in Early Nonresponding Patients With Schizophrenia: A Randomized, Placebo-Controlled Study

Evidence to Support Montgomery-Asberg Depression Rating Scale Administration Every 24 Hours to Assess Rapid Onset of Treatment Response

Efficacy and Safety of Vilazodone in Patients With Generalized Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Trial

Adjunctive Brexpiprazole in Patients With Major Depressive Disorder and Irritability: An Exploratory Study

Time Trends in Lifetime Incidence Rates of First-Time Diagnosed Bipolar and Depressive Disorders Across 16 Years in Danish Psychiatric Hospitals: A Nationwide Study

Reducing Dropout in Treatment for Depression: Translating Dropout Predictors Into Individualized Treatment Recommendations

A Randomized Trial of Dialectical Behavior Therapy in High-Risk Suicidal Veterans

Persistence in Therapy With Risperidone and Aripiprazole in Pediatric Outpatients: A 2-Year Naturalistic Comparison

Adjunctive Taurine in First-Episode Psychosis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study

Generalizability of Neuroimaging Studies in 5 Common Psychiatric Disorders Based on the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer

Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer's Disease

Targeting Treatments to Improve Cognitive Function in Mood Disorder: Suggestions From Trials Using Erythropoietin

Article

Introduction: Focus on Geriatric Psychiatry December 2016

Psychotherapy for Depression in Older Veterans Via Telemedicine: Effect on Quality of Life, Satisfaction, Treatment Credibility, and Service Delivery Perception

Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database

Low Hemoglobin Levels and Risk of Developing Depression in the Elderly: Results From the Prospective PRO.V.A. Study

Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia

Incident Psychosis in Subjects With Mild Cognitive Impairment or Alzheimer's Disease

Commentary

A Radical Proposal to Address the Problem of the Lack of Generalizability of Placebo-Controlled Studies of Antidepressants

Clinical and Practical Psychopharmacology

Antipsychotic Drugs in Schizophrenia: Relative Effects in Patients With and Without Treatment Resistance

Letter to the Editor

The Need to Assess Suicidal Risk in the Checklist for Prescribing Opioids

Clinical Correlates of Oral Glucose Tolerance Test Performance in Olanzapine-Treated Patients with Schizophrenia or Schizoaffective Disorder

Considering the Complexity of Treatment Response in Psychiatric Clinical Trials

Antibiotics or Infection Itself? The Possible Importance of Inflammatory Cytokines on Mental States

Dr Lurie and Colleagues Reply

Correction: Nocturnal Wakefulness Is Associated With Next-Day Suicidal Ideation in Major Depressive Disorder and Bipolar Disorder

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