The Journal of
Clinical Psychiatry

Volume 80 • 2019 • 6

Review Article

The Potential Procognitive Effects of Modafinil in Major Depressive Disorder: A Systematic Review

J Clin Psychiatry 2019;80(6):19r12767

Sophie R. Vaccarino, BScH ; Shane J. McInerney, MD, MSc, MRCPsych ; Sidney H. Kennedy, MD, FRCPC ; Venkat Bhat, MD, MSc, FRCPC

Original Research

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Adjunctive Pimavanserin in Patients With Major Depressive Disorder and an Inadequate Response to Therapy (CLARITY)

J Clin Psychiatry 2019;80(6):19m12928

Maurizio Fava, MD^a ; Bryan Dirks, MD, MBA^b ; Marlene P. Freeman, MD^a ; George I. Papakostas, MD^a ; Richard C. Shelton, MD^c ; Michael E. Thase, MD^d ; Madhukar H. Trivedi, MD^e ; Keith Liu, PhD^b ; Srdjan Stankovic, MD, MSPH^b

Original Research

Impact of Pharmacogenomics on Clinical Outcomes for Patients Taking Medications With Gene-Drug Interactions in a Randomized Controlled Trial

J Clin Psychiatry 2019;80(6):19m12910

Michael E. Thase, MD^a ; Sagar V. Parikh, MD^b ; Anthony J. Rothschild, MD^c ; Boadie W. Dunlop, MD^d ; Charles DeBattista, DMH, MD^e ; Charles R. Conway, MD^f ; Brent P. Forester, MD, MSc^g ; Francis M. Mondimore, MD^h ; Richard C. Shelton, MDⁱ ; Matthew Macaluso, DO^j ; James Li, PhD^k ; Krystal Brown, PhD^l ; Michael R. Jablonski, PhD^k ; John F. Greden, MD^b

Original Research

Influence of Kidney Function on Serum Risperidone Concentrations in Patients Treated With Risperidone

J Clin Psychiatry 2019;80(6):19m12890

Philipp Gründer, MD ; Marc Augustin, MD ; Michael Paulzen, MD ; Gerhard Gründer, MD

Original Research

Prescription Opioid Misuse in US Older Adults: Associated Comorbidities and Reduced Quality of Life in the National Epidemiologic Survey of Alcohol and Related Conditions-III

J Clin Psychiatry 2019;80(6):19m12853

Ty S. Schepis, PhD^a,* ; Sean Esteban McCabe, PhD^b,c,d

Original Research

Adding Increased Energy or Activity to Criterion (A) of the DSM-5 Definition of Hypomania and Mania: Effect on the Diagnoses of 907 Patients From the Bipolar Collaborative Network

J Clin Psychiatry 2019;80(6):19m12834

Mette U. Fredskild, BM ; Jim Mintz, PhD ; Mark A. Frye, MD ; Susan L. McElroy, MD ; Willem A. Nolen, MD, PhD ; Ralph Kupka, MD, PhD ; Heinz Grunze, MD ; Paul E. Keck, Jr., MD ; Robert M. Post, MD ; Lars V. Kessing, MD, PhD ; Trisha Suppes, MD, PhD

Original Research

Trauma Exposure, DSM-5 Posttraumatic Stress, and Binge Eating Symptoms: Results From a Nationally Representative Sample

J Clin Psychiatry 2019;80(6):19m12813

Joel Braun, MD, BSc ; Renée El-Gabalawy, PhD ; Jordana L. Sommer, BA(Hons) ; Robert H. Pietrzak, PhD, MPH ; Karen Mitchell, PhD ; Natalie Mota, PhD

Original Research

Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia

J Clin Psychiatry 2019;80(6):19m12780

Dong-Mei Wang, PhD^a ; Guang-Ya Zhang, MD^b ; Xiang-Dong Du, MD^b ; Qiu-Fang Jia, MD^b ; Zheng-Kang Qian, MD^b ; Guang-Zhong Yin, MD^b ; Yu-Ping Ning, MD, PhD^d,e ; Xing-Bing Huang, MD^d ; Feng-Chun Wu, MD, PhD^d,e

Original Research

Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of Individuals With Treatment-Resistant Depression: Results From the FACE-DR Study

J Clin Psychiatry 2019;80(6):19m12755

Ophélia Godin, PhD^a,b ; Djamila Bennabi, MD, PhD^a,c ; Antoine Yrondi, MD, PhD^a,d ; Raphaëlle Richieri, MD, PhD^a,e ; Thierry D' Amato, MD, PhD^a,f ; Franck Bellivier, MD, PhD^a,g ; Thierry Bougerol, MD, PhD^a,h,i,j ; Mathilde Horn, MD, PhD^a,k ; Vincent Camus, MD, PhD^a,l ; Philippe Courtet, MD, PhD^a,m ; Olivier Doumy, MD, PhD^a,l ; Jean Baptiste Genty, MD, PhD^a,o,p,q ; Wissam El-Hage, MD, PhD^a,h ; Frederic Haesebaert, MD, PhD^a,f ; Jer×´me Holtzmann, MD, PhD^a,h,i,j ; Christophe Lancon, MD, PhD^a,e ; Marion Leboyer, MD, PhD^a,o,p,q ; Pierre Michel Llorca, MD, PhD^a,r ; Julia Maruani, MD, PhD^a,g ; Fanny Moli×¨re, MD, PhD^a,i ; Ludovic Samalin, MD, PhD^a,r ; Laurent Schmitt, MD, PhD^a,d ; Florian Stephan, MD, PhD^a,r ; Guillaume Vaiva, MD, PhD^a,k ; Michel Walter, MD, PhD^a,s ; Bruno Aouizerate, MD, PhD^a,n ; Emmanuel Haffen, MD, PhD^a,c

Original Research

Considerations by Dutch Psychiatrists Regarding Euthanasia and Physician-Assisted Suicide in Psychiatry: A Qualitative Study

J Clin Psychiatry 2019;80(6):19m12736

Rosalie Pronk, MA ; Kirsten Evenblij, MSc ; Dick L. Willems, ProfDr ; Suzanne van de Vathorst, ProfDr

Original Research

A Comparison of Suicide Risk Scales in Predicting Repeat Suicide Attempt and Suicide: A Clinical Cohort Study

J Clin Psychiatry 2019;80(6):18m12707

Åsa U. Lindh, MD, PhD ; Marie Dahlin, MD, PhD ; Karin Beckman, MD, PhD ; Lotta Strömsten, PhD ; Jussi Jokinen, MD, PhD ; Stefan Wiktorsson, PhD ; Ellinor Salander Renberg, PhD ; Margda Waern, MD, PhD ; Bo Runeson, MD, PhD

Original Research

Changes in Metabolic Parameters and Body Weight in Patients With Major Depressive Disorder Treated With Adjunctive Brexpiprazole: Pooled Analysis of Phase 3 Clinical Studies

J Clin Psychiatry 2019;80(6):18m12680

John W. Newcomer, MD ; Hans Eriksson, MD ; Peter Zhang, PhD ; Stine R. Meehan, PhD ; Catherine Weiss, PhD

Original Research

Brain Imaging in Adolescents and Young Adults With First-Episode Psychosis: A Retrospective Cohort Study

J Clin Psychiatry 2019;80(6):18m12665

Sean Andrea, BSc, MD ; Michael Papirny, BSc, MD, FRCPC ; Thomas Raedler, MD

Original Research

Electroencephalogram Resting State Frequency Power Characteristics of Suicidal Behavior in Female Patients With Major Depressive Disorder

J Clin Psychiatry 2019;80(6):18m12661

Lars Benschop, MSc ; Chris Baeken, MD, PhD ; Marie-Anne Vanderhasselt, PhD ; Frederik Van de Steen, PhD ; Kees Van Heeringen, MD, PhD ; Martijn Arns, PhD

Original Research

Predicting Remission in Late-Life Major Depression: A Clinical Algorithm Based Upon Past Treatment History

J Clin Psychiatry 2019;80(6):18m12483

Erica L. F. Buchalter, MD ; Hanadi Ajam Oughli, MD ; Eric J. Lenze, MD ; David Dixon, PhD ; J. Philip Miller ; Daniel M. Blumberger, MD, MSc ; Jordan F. Karp, MD ; Charles F. Reynolds III, MD ; Benoit H. Mulsant, MD, MS

Original Research

Experiential Avoidance Predicts Persistence of Major Depressive Disorder and Generalized Anxiety Disorder in Late Adolescence

J Clin Psychiatry 2019;80(6):18m12265

William H. Mellick, PhD ; James A. Mills, MS ; Emily B. Kroska, PhD ; Chadi A. Calarge, MD ; Carla Sharp, PhD ; Lilian N. Dindo, PhD

Academic Highlights

Current and Emerging Solutions to Challenges in the Management of Alzheimer's Disease

J Clin Psychiatry 2019;80(6):MS18002AH3C

Alireza Atri, MD, PhD ; Danielle Goldfarb, MD ; Simon Sheard, DO ; Lynn Shaughnessy, PsyD

Commentary

Does Pharmacogenomic Testing Meaningfully Improve Antidepressant Treatment Outcomes When Looking Only at Patients Taking Phase I Hepatically Metabolized Drugs? A Little

J Clin Psychiatry 2019;80(6):19com13119

Joseph F. Goldberg, MD

Commentary

Three Clinically Important but Underutilized and Misunderstood Tools: Formulas to Estimate Creatinine Clearance, the Package Insert, and Therapeutic Drug Monitoring

J Clin Psychiatry 2019;80(6):19com13075

Sheldon H. Preskorn, MD

Commentary

Discontinuing Antidepressants: How Can Clinicians Guide Patients and Drive Research?

J Clin Psychiatry 2019;80(6):19com13047

Manish Kumar Jha, MBBS

Commentary

Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs

J Clin Psychiatry 2019;80(6):19com12794

Giovanni A. Fava, MD ; Fiammetta Cosci, MD, PhD

Clinical and Practical Psychopharmacology

Augmentation With Memantine in Obsessive-Compulsive Disorder

J Clin Psychiatry 2019;80(6):19f13163

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Gestational Exposure to Benzodiazepines, 3: Clobazam and Major Congenital Malformations

J Clin Psychiatry 2019;80(6):19f13151

Chittaranjan Andrade, MD

ASCP Corner

Anti-Inflammatory Treatments for Major Depressive Disorder: What's on the Horizon?

J Clin Psychiatry 2019;80(6):18ac12630

Manish Kumar Jha, MD

Letter to the Editor

The Association Between Body Mass Index and Remission Rates in Patients With Treatment-Resistant Depression Who Received Intravenous Ketamine

J Clin Psychiatry 2019;80(6):19l12852

Balwinder Singh, MD, MS ; William V. Bobo, MD, MPH ; Keith G. Rasmussen, MD ; Cynthia J. Stoppel, CCRP ; Jose A. Rico, Jr, CCRP ; Kathryn M. Schak, MD ; Joanna M. Biernacka, PhD ; Mark A. Frye, MD ; Jennifer L. Vande Voort, MD

Educational Activity

Psychosocial Implications of Tardive Dyskinesia in Patients With Mood Disorders Versus Schizophrenia

J Clin Psychiatry 2019;80(6):NU18041BR2C

Joseph P. McEvoy, MD

Volume 80 • 2019 • 6

Review Article

The Potential Procognitive Effects of Modafinil in Major Depressive Disorder: A Systematic Review

Original Research

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Adjunctive Pimavanserin in Patients With Major Depressive Disorder and an Inadequate Response to Therapy (CLARITY)

Impact of Pharmacogenomics on Clinical Outcomes for Patients Taking Medications With Gene-Drug Interactions in a Randomized Controlled Trial

Influence of Kidney Function on Serum Risperidone Concentrations in Patients Treated With Risperidone

Prescription Opioid Misuse in US Older Adults: Associated Comorbidities and Reduced Quality of Life in the National Epidemiologic Survey of Alcohol and Related Conditions-III

Adding Increased Energy or Activity to Criterion (A) of the DSM-5 Definition of Hypomania and Mania: Effect on the Diagnoses of 907 Patients From the Bipolar Collaborative Network

Trauma Exposure, DSM-5 Posttraumatic Stress, and Binge Eating Symptoms: Results From a Nationally Representative Sample

Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia

Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of Individuals With Treatment-Resistant Depression: Results From the FACE-DR Study

Considerations by Dutch Psychiatrists Regarding Euthanasia and Physician-Assisted Suicide in Psychiatry: A Qualitative Study

A Comparison of Suicide Risk Scales in Predicting Repeat Suicide Attempt and Suicide: A Clinical Cohort Study

Changes in Metabolic Parameters and Body Weight in Patients With Major Depressive Disorder Treated With Adjunctive Brexpiprazole: Pooled Analysis of Phase 3 Clinical Studies

Brain Imaging in Adolescents and Young Adults With First-Episode Psychosis: A Retrospective Cohort Study

Electroencephalogram Resting State Frequency Power Characteristics of Suicidal Behavior in Female Patients With Major Depressive Disorder

Predicting Remission in Late-Life Major Depression: A Clinical Algorithm Based Upon Past Treatment History

Experiential Avoidance Predicts Persistence of Major Depressive Disorder and Generalized Anxiety Disorder in Late Adolescence

Academic Highlights

Current and Emerging Solutions to Challenges in the Management of Alzheimer's Disease

Commentary

Does Pharmacogenomic Testing Meaningfully Improve Antidepressant Treatment Outcomes When Looking Only at Patients Taking Phase I Hepatically Metabolized Drugs? A Little

Three Clinically Important but Underutilized and Misunderstood Tools: Formulas to Estimate Creatinine Clearance, the Package Insert, and Therapeutic Drug Monitoring

Discontinuing Antidepressants: How Can Clinicians Guide Patients and Drive Research?

Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs

Clinical and Practical Psychopharmacology

Augmentation With Memantine in Obsessive-Compulsive Disorder

Gestational Exposure to Benzodiazepines, 3: Clobazam and Major Congenital Malformations

ASCP Corner

Anti-Inflammatory Treatments for Major Depressive Disorder: What's on the Horizon?

Letter to the Editor

The Association Between Body Mass Index and Remission Rates in Patients With Treatment-Resistant Depression Who Received Intravenous Ketamine

Educational Activity

Psychosocial Implications of Tardive Dyskinesia in Patients With Mood Disorders Versus Schizophrenia

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Volume 80 • 2019 • 6

Review Article

The Potential Procognitive Effects of Modafinil in Major Depressive Disorder: A Systematic Review

Original Research

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of Adjunctive Pimavanserin in Patients With Major Depressive Disorder and an Inadequate Response to Therapy (CLARITY)

Impact of Pharmacogenomics on Clinical Outcomes for Patients Taking Medications With Gene-Drug Interactions in a Randomized Controlled Trial

Influence of Kidney Function on Serum Risperidone Concentrations in Patients Treated With Risperidone

Prescription Opioid Misuse in US Older Adults: Associated Comorbidities and Reduced Quality of Life in the National Epidemiologic Survey of Alcohol and Related Conditions-III

Adding Increased Energy or Activity to Criterion (A) of the DSM-5 Definition of Hypomania and Mania: Effect on the Diagnoses of 907 Patients From the Bipolar Collaborative Network

Trauma Exposure, DSM-5 Posttraumatic Stress, and Binge Eating Symptoms: Results From a Nationally Representative Sample

Sex Differences in the Prevalence and Clinical Features of Comorbid Depressive Symptoms in Never-Treated Chinese Patients With First-Episode Schizophrenia

Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of Individuals With Treatment-Resistant Depression: Results From the FACE-DR Study

Considerations by Dutch Psychiatrists Regarding Euthanasia and Physician-Assisted Suicide in Psychiatry: A Qualitative Study

A Comparison of Suicide Risk Scales in Predicting Repeat Suicide Attempt and Suicide: A Clinical Cohort Study

Changes in Metabolic Parameters and Body Weight in Patients With Major Depressive Disorder Treated With Adjunctive Brexpiprazole: Pooled Analysis of Phase 3 Clinical Studies

Brain Imaging in Adolescents and Young Adults With First-Episode Psychosis: A Retrospective Cohort Study

Electroencephalogram Resting State Frequency Power Characteristics of Suicidal Behavior in Female Patients With Major Depressive Disorder

Predicting Remission in Late-Life Major Depression: A Clinical Algorithm Based Upon Past Treatment History

Experiential Avoidance Predicts Persistence of Major Depressive Disorder and Generalized Anxiety Disorder in Late Adolescence

Academic Highlights

Current and Emerging Solutions to Challenges in the Management of Alzheimer's Disease

Commentary

Does Pharmacogenomic Testing Meaningfully Improve Antidepressant Treatment Outcomes When Looking Only at Patients Taking Phase I Hepatically Metabolized Drugs? A Little

Three Clinically Important but Underutilized and Misunderstood Tools: Formulas to Estimate Creatinine Clearance, the Package Insert, and Therapeutic Drug Monitoring

Discontinuing Antidepressants: How Can Clinicians Guide Patients and Drive Research?

Understanding and Managing Withdrawal Syndromes After Discontinuation of Antidepressant Drugs

Clinical and Practical Psychopharmacology

Augmentation With Memantine in Obsessive-Compulsive Disorder

Gestational Exposure to Benzodiazepines, 3: Clobazam and Major Congenital Malformations

ASCP Corner

Anti-Inflammatory Treatments for Major Depressive Disorder: What's on the Horizon?

Letter to the Editor

The Association Between Body Mass Index and Remission Rates in Patients With Treatment-Resistant Depression Who Received Intravenous Ketamine

Educational Activity

Psychosocial Implications of Tardive Dyskinesia in Patients With Mood Disorders Versus Schizophrenia

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