The Journal of
Clinical Psychiatry

Volume 82 • 2021 • 4

Systematic Review

Ketamine Treatment for Depression in Patients With a History of Psychosis or Current Psychotic Symptoms: A Systematic Review

J Clin Psychiatry 2021;82(4):20r13459

Jolien K. E. Veraart, MD; Sanne Y. Smith-Apeldoorn, MD; Jan Spijker, MD, PhD; Jeanine Kamphuis, MD, PhD; Robert A. Schoevers, MD, PhD

Meta-Analysis

Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset

J Clin Psychiatry 2021;82(4):20r13682

Nadia Iovieno, MD; George I. Papakostas, MD; Anna Feeney, MD; Maurizio Fava, MD; Sanjay J. Mathew, MD; Dan I. Iosifescu, MD, MSc; James W. Murrough, MD, PhD; Matthew Macaluso, DO; Rebecca S. Hock, PhD; Manish K. Jha, MD

Original Research

Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed

J Clin Psychiatry 2021;82(4):20m13795

Leslie Citrome, MD, MPH; Timothy Juday, PhD, MPA; Feride Frech, PhD, MPH; Norman Atkins, Jr, PhD, MBA

Original Research

Postpartum Depression and Psychosis and Subsequent Severe Mental Illnesses in Mothers and Neurodevelopmental Disorders in Children: A Nationwide Study

J Clin Psychiatry 2021;82(4):20m13735

Mu-Hong Chen, MD, PhD; Tai-Long Pan, PhD; Ya-Mei Bai, MD, PhD; Kai-Lin Huang, MD; Shih-Jen Tsai, MD; Tung-Ping Su, MD; Tzeng-Ji Chen, MD, PhD; Ju-Wei Hsu, MD

Original Research

A Placebo-Controlled Trial of Lisdexamfetamine in the Treatment of Comorbid Sluggish Cognitive Tempo and Adult ADHD

J Clin Psychiatry 2021;82(4):20m13687

Lenard A. Adler, MD; Terry L. Leon, MS, RN; Taylor M. Sardoff, BA; Beth Krone, PhD; Stephen V. Faraone, PhD; Michael J. Silverstein, MS; Jeffrey H. Newcorn, MD

Original Research

Treatment Response With Esketamine Nasal Spray Plus an Oral Antidepressant in Patients With Treatment-Resistant Depression Without Evidence of Early Response: A Pooled Post Hoc Analysis of the TRANSFORM Studies

J Clin Psychiatry 2021;82(4):20m13800

Ibrahim Turkoz, PhD; Ella Daly, MD; Jaskaran Singh, MD; Xiwu Lin, PhD; Yevgen Tymofyeyev, PhD; David Williamson, PhD; Giacomo Salvadore, MD; Abigail I. Nash, MD, PhD; Matthew Macaluso, DO; Samuel T. Wilkinson, MD; J. Craig Nelson, MD

Original Research

Cigarette Use and Cannabis Use Disorder Onset, Persistence, and Relapse: Longitudinal Data From a Representative Sample of US Adults

J Clin Psychiatry 2021;82(4):20m13713

Andrea H. Weinberger, PhD; Jonathan Platt, PhD, MPH; Jiaqi Zhu, MA; Jacob Levin, BA; Ollie Ganz, DrPH; Renee D. Goodwin, PhD, MPH

Original Research

Depression, Anxiety, and Mother-Infant Bonding in Women Seeking Treatment for Postpartum Depression Before and During the COVID-19 Pandemic

J Clin Psychiatry 2021;82(4):21m13874

Haley Layton, MPH; Sawayra Owais, MSc; Calan D. Savoy, MSc; Ryan J. Van Lieshout, MD, PhD

Original Research

A Nationwide Cohort Study of Parasomnias Among Adolescents

J Clin Psychiatry 2021;82(4):20m13648

Yu Kinoshita, MD; Osamu Itani, MD, PhD; Yuichiro Otsuka, MD, PhD, MPH; Yuuki Matsumoto, MD, PhD; Sachi Nakagome, MD, PhD; Yoshitaka Kaneita, MD, PhD

Original Research

Sex Differences in Recovery-Related Outcomes and Needs for Psychiatric Rehabilitation in People With Schizophrenia Spectrum Disorder

J Clin Psychiatry 2021;82(4):20m13732

Original Research

Symptomatic and Functional Response and Remission From the Open-Label Treatment-Optimization Phase of a Study With DR/ER-MPH in Children With ADHD

J Clin Psychiatry 2021;82(4):21m13914

Ann C. Childress, MD; Andrew J. Cutler, MD; Michelle D. Po, PhD; Norberto J. DeSousa, MA; Lewis E. Warrington, MD; Floyd R. Sallee, MD, PhD; Bev Incledon, PhD

Original Research

Reproductive Safety of Second-Generation Antipsychotics: Updated Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics

J Clin Psychiatry 2021;82(4):20m13745

Adele C. Viguera, MD, MPH; Marlene P. Freeman, MD; Lina Góez-Mogollón, MD, MSc; Alexandra Z. Sosinsky, MS; Sara A. McElheny, BA; Taylor R. Church, BS; Amanda V. Young, BA; Phoebe S. Caplin, BA; David Chitayat, MD; Sonia Hernández-Díaz, MPH, DrPH; Lee S. Cohen, MD

Original Research

Predictors of Response to Prolonged Exposure, Sertraline, and Their Combination for the Treatment of Military PTSD

J Clin Psychiatry 2021;82(4):20m13752

Sheila A. M. Rauch, PhD; H. Myra Kim, ScD; Seth Lederman, MD; Gregory Sullivan, MD; Ron Acierno, PhD; Peter W. Tuerk, PhD; Naomi M. Simon, MD; Margaret R. Venners, MPH, MSW; Sonya B. Norman, PhD; Carolyn B. Allard, PhD; Katherine E. Porter, PhD; Brian Martis, MD; Eric Bui, MD; Amanda W. Baker, PhD

Academic Highlights

Relieving Caregiver Burden Through Evidence-Based Treatment for Dementia-Related Psychosis

J Clin Psychiatry 2021;82(4):AD19038AH5C

Clive Ballard, MBChB, MMedSci, MRCPsych, MD; Dag Aarsland, MD, PhD

Academic Highlights

Treatment Challenges and the Hope of Emerging Therapies in Early-Stage Alzheimer Disease

J Clin Psychiatry 2021;82(4):BG20044AH4C

Anna D. Burke, MD; Liana Apostolova, MD, MSc

Commentary

The Importance of Context in Identifying the Recovery Needs of Women With Psychosis

J Clin Psychiatry 2021;82(4):21com13936

Ann K. Shinn, MD, MPH; Emily E. Carol, PhD

Commentary

No Simple Decisions for Psychiatrically Ill Pregnant Women

J Clin Psychiatry 2021;82(4):21com14044

Vivien K. Burt, MD PhD; Sonya Rasminsky, MD

Clinical and Practical Psychopharmacology

Anesthesia for Electroconvulsive Therapy: A Niche Role for Sevoflurane

J Clin Psychiatry 2021;82(4):21f14173

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Predictors of 6- and 12-Month Relapse After Stopping Electroconvulsive Therapy: Critical Considerations, Including Overfitting in Regression and Confounding in Follow-up Studies

J Clin Psychiatry 2021;82(4):21f14174

Chittaranjan Andrade, MD

ASCP Corner

Investigational Treatment of Depressive Disorders With Neuroactive Steroids: Potential Implications for Premenstrual Dysphoric Disorder

J Clin Psychiatry 2021;82(4):20ac13853

Mercedes J. Szpunar, MD, PhD; Marlene P. Freeman, MD

Case Series

Six Cases of Perforated Appendicitis During Clozapine Treatment

J Clin Psychiatry 2021;82(4):20cr13841

Tilman Steinert, Prof. Dr. med.; Franziska Jans, MD

Letter to the Editor

Antidepressant Effects of Combined Mood Stabilizers May Account for High Placebo Response Rates

J Clin Psychiatry 2021;82(4):21lr13919

Takeshi Terao, MD, PhD

Letter to the Editor

Antidepressants Added Nothing to Mood Stabilizers Alone: Reply to Terao

J Clin Psychiatry 2021;82(4):21lr13919a

S. Nassir Ghaemi, MD, MPH

Letter to the Editor

Adjunctive Mood Stabilizers Are Not the Same as a Placebo-Only Arm in Bipolar Depression Trials: Reply to Terao

J Clin Psychiatry 2021;82(4):21lr13919b

Joseph F. Goldberg, MD

Educational Activity

Challenges in Managing Insomnia in Older People

J Clin Psychiatry 2021;82(4):EI20008BR3C

Andrew D. Krystal, MD

Educational Activity

Diagnosis and Pharmacotherapy of Bipolar Depression in Pediatric Patients

J Clin Psychiatry 2021;82(4):SU20014BR2C

Robert L. Findling, MD, MBA

Educational Activity

Diagnosis and Pharmacotherapy of Bipolar Depression in Adults

J Clin Psychiatry 2021;82(4):SU120014BR1C

Joseph F. Goldberg, MD

Educational Activity

Optimizing Treatment for Insomnia

J Clin Psychiatry 2021;82(4):EI20008BR4C

Andrew D. Krystal, MD

Volume 82 • 2021 • 4

Systematic Review

Ketamine Treatment for Depression in Patients With a History of Psychosis or Current Psychotic Symptoms: A Systematic Review

Meta-Analysis

Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset

Original Research

Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed

Postpartum Depression and Psychosis and Subsequent Severe Mental Illnesses in Mothers and Neurodevelopmental Disorders in Children: A Nationwide Study

A Placebo-Controlled Trial of Lisdexamfetamine in the Treatment of Comorbid Sluggish Cognitive Tempo and Adult ADHD

Treatment Response With Esketamine Nasal Spray Plus an Oral Antidepressant in Patients With Treatment-Resistant Depression Without Evidence of Early Response: A Pooled Post Hoc Analysis of the TRANSFORM Studies

Cigarette Use and Cannabis Use Disorder Onset, Persistence, and Relapse: Longitudinal Data From a Representative Sample of US Adults

Depression, Anxiety, and Mother-Infant Bonding in Women Seeking Treatment for Postpartum Depression Before and During the COVID-19 Pandemic

A Nationwide Cohort Study of Parasomnias Among Adolescents

Sex Differences in Recovery-Related Outcomes and Needs for Psychiatric Rehabilitation in People With Schizophrenia Spectrum Disorder

Symptomatic and Functional Response and Remission From the Open-Label Treatment-Optimization Phase of a Study With DR/ER-MPH in Children With ADHD

Reproductive Safety of Second-Generation Antipsychotics: Updated Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics

Predictors of Response to Prolonged Exposure, Sertraline, and Their Combination for the Treatment of Military PTSD

Academic Highlights

Relieving Caregiver Burden Through Evidence-Based Treatment for Dementia-Related Psychosis

Treatment Challenges and the Hope of Emerging Therapies in Early-Stage Alzheimer Disease

Commentary

The Importance of Context in Identifying the Recovery Needs of Women With Psychosis

No Simple Decisions for Psychiatrically Ill Pregnant Women

Clinical and Practical Psychopharmacology

Anesthesia for Electroconvulsive Therapy: A Niche Role for Sevoflurane

Predictors of 6- and 12-Month Relapse After Stopping Electroconvulsive Therapy: Critical Considerations, Including Overfitting in Regression and Confounding in Follow-up Studies

ASCP Corner

Investigational Treatment of Depressive Disorders With Neuroactive Steroids: Potential Implications for Premenstrual Dysphoric Disorder

Case Series

Six Cases of Perforated Appendicitis During Clozapine Treatment

Letter to the Editor

Antidepressant Effects of Combined Mood Stabilizers May Account for High Placebo Response Rates

Antidepressants Added Nothing to Mood Stabilizers Alone: Reply to Terao

Adjunctive Mood Stabilizers Are Not the Same as a Placebo-Only Arm in Bipolar Depression Trials: Reply to Terao

Educational Activity

Challenges in Managing Insomnia in Older People

Diagnosis and Pharmacotherapy of Bipolar Depression in Pediatric Patients

Diagnosis and Pharmacotherapy of Bipolar Depression in Adults

Optimizing Treatment for Insomnia

Celebrating85 Years

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85 Years

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