The Journal of
Clinical Psychiatry

Volume 83 • 2022 • 4

In Memoriam

In Memoriam: Jan Fawcett, MD, 1934–2022

J Clin Psychiatry 2022;83(4):22f14557

A. John Rush, MD ; Steven D. Hollon, PhD

Meta-Analysis

Real-Time Telehealth Versus Face-to-Face Management for Patients With PTSD in Primary Care: A Systematic Review and Meta-Analysis

J Clin Psychiatry 2022;83(4):21r14143

Anna Mae Scott, PhD ; Mina Bakhit, PhD ; Hannah Greenwood, BSc(Hons) ; Magnolia Cardona, PhD ; Justin Clark, BA ; Natalia Krzyzaniak, PhD ; Ruwani Peiris, MD ; Paul Glasziou, PhD

Original Research

Long-term Outcomes of Early Use of Long-Acting Injectable Antipsychotics in Schizophrenia

J Clin Psychiatry 2022;83(4):21r14153

Su-Chen Fang, PhD^a ; Cheng-Yi Huang, MD^b ; Yu-Hsuan Joni Shao, PhD^c,d

Original Research

Moderation of Risks to Sexual Health by Substance Use in College Students With ADHD

J Clin Psychiatry 2022;83(4):21m14240

Ashley M. Rohacek, BS ; Madison K. Firkey, MS ; Sarah E. Woolf-King, PhD, MPH ; Kevin M. Antshel, PhD

Original Research

Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI)

J Clin Psychiatry 2022;83(4):21m14345

Dan V. Iosifescu, MD^a ; Amanda Jones, PharmD^b ; Cedric O’Gorman, MD^b,e ; Caroline Streicher^b ; Samantha Feliz^b ; Maurizio Fava, MD^c,d ; Herriot Tabuteau, MD^b

Original Research

Incidence and Predictors of Suicide Attempts and Suicide Deaths Among Individuals Recently Hospitalized for a Mental Disorder: A Population-Based Study

J Clin Psychiatry 2022;83(4):21m14055

Jessica S. Enns, MD^a ; Natalie P. Mota, PhD^b ; James M. Bolton, MD^a ; Okechukwu Ekuma, MSc^c ; Dan Chateau, PhD^d ; Michelle M. Paluszek, MA^e ; Jitender Sareen, MD^a ; Laurence Y. Katz, MD^a

Original Research

Efficacy of HP-3070, an Asenapine Transdermal System, on Symptoms of Hostility in Adults With Schizophrenia: A Post Hoc Analysis of a 6-Week Phase 3 Study

J Clin Psychiatry 2022;83(4):21m14355

Leslie Citrome, MD, MPH^a ; Marina Komaroff, DrPH^b ; Brittney Starling, PharmD^b ; Sandeep Byreddy, MS^b ; Takaaki Terahara, PhD^c ; Masami Hasebe, MPharm^c

Original Research

Toward a Definition of “No Meaningful Benefit” From Antidepressant Treatment: An Equipercentile Analysis With Cross-Trial Validation Across Multiple Rating Scales

J Clin Psychiatry 2022;83(4):21m14239

Carl Zhang^a ; Sanya Virani, MD^b ; Taryn Mayes, MS^c ; Thomas Carmody, PhD^d ; Paul E. Croarkin, DO^e ; Richard Weinshilboum, MD^a ; A. John Rush, MD^f,g ; Madhukar Trivedi, MD^c ; Arjun P. Athreya, PhD^a ; William V. Bobo, MD^h

Original Research

Youth Aware of Mental Health (YAM) Program With Texas Adolescents: Depression, Anxiety, and Substance Use Outcomes

J Clin Psychiatry 2022;83(4):21m14221

Madhukar H. Trivedi, MD^a ; Karabi Nandy, PhD^b ; Taryn L. Mayes, MS^a ; Tianyi Wang, MS^a ; Kathryn Forbes, MS^a ; Jacqueline R. Anderson, PhD^c ; Anne Fuller, PhD^d ; Jennifer L. Hughes, PhD, MPH^a,e

Original Research

Daily Dose Effects of Risperidone on Weight and Other Metabolic Parameters: A Prospective Cohort Study

J Clin Psychiatry 2022;83(4):21m14110

Marianna Piras, PharmD^a ; Céline Dubath, PhD^a ; Mehdi Gholam, PhD^b ; Nermine Laaboub, MSc^a ; Claire Grosu, MSc^a ; Franziska Gamma, MD, MSc^c ; Alessandra Solida, MD^d ; Kerstin Jessica Plessen, PhD^e ; Armin von Gunten, MPhil, MD^f ; Philippe Conus, MD^d ; Chin B. Eap, PhD^a,g,h,i,*

Original Research

Maternal Postnatal Depression and Completion of Infant Immunizations: A UK Cohort Study of 196,329 Mother-Infant Pairs, 2006–2015

J Clin Psychiatry 2022;83(4):20m13575

Holly C. Smith, MSc ; Sonia Saxena, MBBS, Msc, MD, FRCGP ; Irene Petersen, PhD, MSc

Original Research

Comorbid Eating Disorders in a Sample of Youth With Bipolar Disorder: Elevated Burden of Dimensional and Categorical Psychopathology

J Clin Psychiatry 2022;83(4):21m14201

Diana Khoubaeva, BSc, Hons^a ; Mikaela K. Dimick, BA^a,d ; Jessica L. Roane, MSW^a ; Vanessa H. Timmins, MSW^a ; Rachel H. B. Mitchell, MD, MSc^b,c ; Benjamin I. Goldstein, MD, PhD^a,b,d

Original Research

Utility and Barriers to Clozapine Use: A Joint Study of Clinicians’ Attitudes From Singapore and Hong Kong

J Clin Psychiatry 2022;83(4):21m14231

Shushan Zheng, MBBS, MRCPsych (UK)^a,b,* ; Jimmy Lee, MBBS, MMed (Psych), MCI^a,b ; Sherry Kit Wa Chan, MBBS, MRCPsych (UK)^c,d

Original Research

The Relationship Between Mental Pain, Suicide Risk, and Childhood Traumatic Experiences: Results From a Multicenter Study

J Clin Psychiatry 2022;83(4):21m14176

Maurizio Pompili, MD, PhD^a ; Denise Erbuto, PsyD, PhD^a ; Marco Innamorati, PsyD, PhD^b ; Mario Luciano, MD^c ; Gaia Sampogna, MD^c ; Giovanni Abbate-Daga, MD^d ; Stefano Barlati, MD^e ; Claudia Carmassi, MD^f ; Giovanni Castellini, MD^g ; Pasquale De Fazio, MD^h ; Giorgio Di Lorenzo, MDⁱ ; Marco Di Nicola, MD^j,k ; Silvia Ferrari, MD^l ; Carla Gramaglia, MD^m ; Maria Giulia Nanni, MDⁿ ; Massimo Pasquini, MD^o ; Federica Pinna, MD^p ; Nicola Poloni, MD^q ; Gianluca Serafini, MD, PhD^r ; Maria Signorelli, MD^s ; Antonio Ventriglio, MD^t ; Umberto Volpe, MD^u ; Andrea Fiorillo, MD, PhD^c

Original Research

Association of Bupropion, Naltrexone, and Opioid Agonist Treatment With Stimulant-Related Admissions Among People With Opioid Use Disorder: A Case-Crossover Analysis

J Clin Psychiatry 2022;83(4):21m14112

Kevin Y. Xu, MD, MPH^a,* ; Carrie M. Mintz, MD^a ; Ned Presnall, MSW^a ; Laura J. Bierut, MD^a,b ; Richard A. Grucza, PhD^a,c

Original Research

Nocturnal Wakefulness and Suicide Risk in the Australian Population

J Clin Psychiatry 2022;83(4):21m14275

Darren R. Mansfield, PhD^a,b,* ; Sanjiwika Wasgewatta, MBBS^a ; Amy Reynolds, PhD^c ; Michael A. Grandner, PhD^d ; Andrew S. Tubbs, BSc^d ; Kylie King, PhD^a ; Michael Johnson, MEI^f ; Luis Mascaro, BPsych^a ; Melodi Durukan, BPsych^a ; Eldho Paul, PhD^g ; Sean P. A. Drummond, PhD^a ; Michael L. Perlis, PhD^e

Original Research

Pregnancy Outcomes With Exposure to Second-Generation Antipsychotics During the First Trimester

J Clin Psychiatry 2022;83(4):21m14081

Naho Yakuwa, BPharm^a,b,* ; Kunihiko Takahashi, PhD^c ; Tatsuhiko Anzai, PhD^c ; Naoki Ito, MD, PhD^a,d ; Mikako Goto, MD, PhD^a ; Sachi Koinuma, MD^a ; Chiaki Uno, BPharm^a,e ; Tomo Suzuki, MD^a,f ; Omi Watanabe, MD^a ; Akimasa Yamatani, PhD^a,e ; Atsuko Murashima, MD, PhD^a,f

Original Research

Treatment-Resistant Mood Disorders in LGBTQ People: A Retrospective Study of Clinical Features and Response to Electroconvulsive Therapy

J Clin Psychiatry 2022;83(4):21m14321

Fumie Oka, MD^a ; Kamile Weischedel, MD^a ; Amanda Bakian, PhD^a ; Brian J. Mickey, MD, PhD^a

Academic Highlights

Patient Functioning and Life Engagement: Unmet Needs in Major Depressive Disorder and Schizophrenia

J Clin Psychiatry 2022;83(4):LU21112AH1

Christoph U. Correll, MD ; Zahinoor Ismail, MD ; Roger S. McIntyre, MD ; Roueen Rafeyan, MD ; Michael E. Thase, MD

Cross Talk: Case Conferences From MGH

Treatment of Overthinking: A Multidisciplinary Approach to Rumination and Obsession Spectrum

J Clin Psychiatry 2022;83(4):21ct14543

Alice Flaherty, MD, PhD^{a, ‡, *,} ; Douglas Katz, PhD^{b, ‡} ; Anne Chosak, PhD^c ; Michael E. Henry, MD^d ; Nhi-Ha Trinh, MD, MPH^e ; Robert J. Waldinger, MD^f ; Jonah N. Cohen, PhD^g

Commentary

Should Blind Psychiatrists Be Paid Less?

J Clin Psychiatry 2022;83(4):21com14354

Mark Zimmerman, MD

Commentary

Accumulation of Reproductive Safety Data for Second-Generation Atypical Antipsychotics: A Call to Accelerate the Process

J Clin Psychiatry 2022;83(4):22com14489

Adele C. Viguera, MD, MPH^a,b,c

Commentary

Psychiatric Care Considerations for Sexually and Gender Diverse Populations

J Clin Psychiatry 2022;83(4):22com14579

Alex S. Keuroghlian, MD, MPH^a,b,c

Clinical and Practical Psychopharmacology

The Practical Importance of Half-Life in Psychopharmacology

J Clin Psychiatry 2022;83(4):22f14584

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Psychotropic Drugs With Long Half-Lives: Implications for Drug Discontinuation, Occasional Missed Doses, Dosing Interval, and Pregnancy Planning

J Clin Psychiatry 2022;83(4):22f14593

Chittaranjan Andrade, MD

ASCP Corner

Best Practices for Starting Clozapine in Patients With Schizophrenia: How to Switch From the Prior Antipsychotic(s)

J Clin Psychiatry 2022;83(4):22ac14500

Georgios Schoretsanitis, MD^a,b,c ; Jose de Leon, MD^d,e

Brief Report

Psychiatric Patients Who Do Not Believe They Deserve to Get Better

J Clin Psychiatry 2022;83(4):21br14314

Mark Zimmerman, MD ; Lena Becker, BS

Brief Report

Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans

J Clin Psychiatry 2022;83(4):21br14309

Peter J. Na, MD, MPH^a,b,* ; Janitza L. Montalvo-Ortiz, PhD^a,b ; Sheila T. Nagamatsu, PhD^a,b ; Steven M. Southwick, MD^b ; John H. Krystal, MD^b,c ; Joel Gelernter, MD^b,c ; Robert H. Pietrzak, PhD, MPH^b,c,d

Brief Report

Factors Associated With Remission of Suicidal Ideation During the COVID-19 Pandemic: A Population-Based, Longitudinal Study in US Military Veterans

J Clin Psychiatry 2022;83(4):21br14341

Sarah Herzog, PhD^a,b,* ; Brandon Nichter, PhD^c ; Melanie L. Hill, PhD^d,e ; Peter J. Na, MD^c,f ; Sonya B. Norman, PhD^d,g,h ; Robert H. Pietrzak, PhD^c,i,j

Educational Activity

Timely Diagnosis of Alzheimer Disease

J Clin Psychiatry 2022;83(4):LI21019DH1C

Anna D. Burke, MD ; Danielle Goldfarb, MD

Educational Activity

Facilitating Treatment Initiation in Early-Stage Alzheimer Disease

J Clin Psychiatry 2022;83(4):LI21019DH2C

Anna D. Burke, MD ; Danielle Goldfarb, MD

Volume 83 • 2022 • 4

In Memoriam

In Memoriam: Jan Fawcett, MD, 1934–2022

Meta-Analysis

Real-Time Telehealth Versus Face-to-Face Management for Patients With PTSD in Primary Care: A Systematic Review and Meta-Analysis

Original Research

Long-term Outcomes of Early Use of Long-Acting Injectable Antipsychotics in Schizophrenia

Moderation of Risks to Sexual Health by Substance Use in College Students With ADHD

Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI)

Incidence and Predictors of Suicide Attempts and Suicide Deaths Among Individuals Recently Hospitalized for a Mental Disorder: A Population-Based Study

Efficacy of HP-3070, an Asenapine Transdermal System, on Symptoms of Hostility in Adults With Schizophrenia: A Post Hoc Analysis of a 6-Week Phase 3 Study

Toward a Definition of “No Meaningful Benefit” From Antidepressant Treatment: An Equipercentile Analysis With Cross-Trial Validation Across Multiple Rating Scales

Youth Aware of Mental Health (YAM) Program With Texas Adolescents: Depression, Anxiety, and Substance Use Outcomes

Daily Dose Effects of Risperidone on Weight and Other Metabolic Parameters: A Prospective Cohort Study

Maternal Postnatal Depression and Completion of Infant Immunizations: A UK Cohort Study of 196,329 Mother-Infant Pairs, 2006–2015

Comorbid Eating Disorders in a Sample of Youth With Bipolar Disorder: Elevated Burden of Dimensional and Categorical Psychopathology

Utility and Barriers to Clozapine Use: A Joint Study of Clinicians’ Attitudes From Singapore and Hong Kong

The Relationship Between Mental Pain, Suicide Risk, and Childhood Traumatic Experiences: Results From a Multicenter Study

Association of Bupropion, Naltrexone, and Opioid Agonist Treatment With Stimulant-Related Admissions Among People With Opioid Use Disorder: A Case-Crossover Analysis

Nocturnal Wakefulness and Suicide Risk in the Australian Population

Pregnancy Outcomes With Exposure to Second-Generation Antipsychotics During the First Trimester

Treatment-Resistant Mood Disorders in LGBTQ People: A Retrospective Study of Clinical Features and Response to Electroconvulsive Therapy

Academic Highlights

Patient Functioning and Life Engagement: Unmet Needs in Major Depressive Disorder and Schizophrenia

Cross Talk: Case Conferences From MGH

Treatment of Overthinking: A Multidisciplinary Approach to Rumination and Obsession Spectrum

Commentary

Should Blind Psychiatrists Be Paid Less?

Accumulation of Reproductive Safety Data for Second-Generation Atypical Antipsychotics: A Call to Accelerate the Process

Psychiatric Care Considerations for Sexually and Gender Diverse Populations

Clinical and Practical Psychopharmacology

The Practical Importance of Half-Life in Psychopharmacology

Psychotropic Drugs With Long Half-Lives: Implications for Drug Discontinuation, Occasional Missed Doses, Dosing Interval, and Pregnancy Planning

ASCP Corner

Best Practices for Starting Clozapine in Patients With Schizophrenia: How to Switch From the Prior Antipsychotic(s)

Brief Report

Psychiatric Patients Who Do Not Believe They Deserve to Get Better

Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans

Factors Associated With Remission of Suicidal Ideation During the COVID-19 Pandemic: A Population-Based, Longitudinal Study in US Military Veterans

Educational Activity

Timely Diagnosis of Alzheimer Disease

Facilitating Treatment Initiation in Early-Stage Alzheimer Disease

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