The Journal of
Clinical Psychiatry

Volume 83 • 2022 • 6

Editorial

Prescribing Guideline for Valproic Acid and Women of Reproductive Potential: Forget It Exists

J Clin Psychiatry 2022;83(6):22ed14609

Marlene P. Freeman, MD

Editorial

Living in a Pharmacologically Imperfect World

J Clin Psychiatry 2022;83(6):22ed14665

Joseph F. Goldberg, MD

Systematic Review

Relationship of Premenstrual Dysphoric Disorder With Bipolar Disorder: A Systematic Review

J Clin Psychiatry 2022;83(6):22r14416

Verinder Sharma, MBBS^a,b,c,* ; Dwight Mazmanian, PhD, CPsych^d ; Heidi Eccles, MSc^c

Systematic Review

Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review

J Clin Psychiatry 2022;83(6):21r14328

Alix M. Arnaud, MSc ; Teri S. Brister, PhD ; Ken Duckworth, MD ; Phyllis Foxworth, BSc ; Tonya Fulwider, BA ; Ellison D. Suthoff, MBA ; Brian Werneburg, PhD ; Izabela Aleksanderek, PhD ; Marcia L. Reinhart, DPhil

Systematic Review

A Systematic Review of Fear Learning, Extinction Learning, and Reversal Learning in Obsessive-Compulsive Disorder: Implications for Treatment

J Clin Psychiatry 2022;83(6):21r14432

Elizabeth R. Steuber, MD^a ; Joseph F. McGuire, PhD^a,b

Systematic Review

Differential Engagement by Race/Ethnicity in Experimental Trials of Mental Health Treatment Interventions: A Systematic Review

J Clin Psychiatry 2022;83(6):21r14343

Peter C. Lam, MPH^a ; Danielle Simpson, MD^b ; Dolly A. John, PhD^a ; Micaela Rodriguez, BA^c ; David Bridgman-Packer, MD, MPH^d ; Amanda Gabrielle Cruz, MS^e ; Maeve A. O’Neill, MD^f ; Roberto Lewis-Fernández, MD^a,g

Systematic Review

Safety of Ketamine Augmentation to Monoamine Oxidase Inhibitors in Treatment-Resistant Depression: A Systematic Literature Review and Case Series

J Clin Psychiatry 2022;83(6):21m14267

Jolien K. E. Veraart, MD^a,b,* ; Sanne Y. Smith-Apeldoorn, MD^a ; Mats Kutscher, MSc^a ; Maurice Vischjager, MSc^a ; Annemarie van der Meij, MD^c ; Jeanine Kamphuis, MD, PhD^a ; Robert A. Schoevers, MD, PhD^a,d

Original Research

Clinical Effectiveness of Intravenous Racemic Ketamine Infusions in a Large Community Sample of Patients With Treatment-Resistant Depression, Suicidal Ideation, and Generalized Anxiety Symptoms: A Retrospective Chart Review

J Clin Psychiatry 2022;83(6):21m14336

Patrick A. Oliver, MD^a ; Andrew D. Snyder, MD^b,c ; Richard Feinn, PhD^d ; Stanislav Malov, MD^b ; Gray McDiarmid, BSc^b ; Albert J. Arias, MD, MS^b,c

Original Research

The Economic Burden of Schizophrenia in the United States

J Clin Psychiatry 2022;83(6):22m14458

Aditi Kadakia, MS^a ; Maryaline Catillon, PhD^b ; Qi Fan, MS^a ; G. Rhys Williams, PhD^a ; Jessica R. Marden, ScD^c ; Annika Anderson, MPH^b ; Noam Kirson, PhD^c ; Carole Dembek, MS^a

Original Research

Psychiatric Diagnoses Among Transgender and Gender Diverse Patients Compared to Cisgender Patients

J Clin Psychiatry 2022;83(6):21m14062

Mark Zimmerman, MD^a ; Isabel Benjamin, BA^a ; Craig Seijas-Rodriguez, PhD^b

Original Research

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial

J Clin Psychiatry 2022;83(6):22m14447

Leslie Citrome, MD, MPH^a ; Sheldon H. Preskorn, MD^b ; John Lauriello, MD^c ; John H. Krystal, MD^d ; Rishi Kakar, MD^e ; Jeffrey Finman, PhD^f ; Michael De Vivo, PhD^g ; Frank D. Yocca, PhD^g ; Robert Risinger, MD^g ; Lavanya Rajachandran, PhD^g

Original Research

Longitudinal Course of Adverse Events With Esketamine Nasal Spray: A Post Hoc Analysis of Pooled Data From Phase 3 Trials in Patients With Treatment-Resistant Depression

J Clin Psychiatry 2022;83(6):21m14318

David J. Williamson, PhD^a,‡ ; Jagadish P. Gogate, PhD^b ; Jennifer K. Kern Sliwa, PharmD^c ; Lewis S. Manera, MS^d,‡ ; Sheldon H. Preskorn, MD^e ; Andrew Winokur, PhD, MD^f ; H. Lynn Starr, MD^g ; Ella J. Daly, MD^a,‡

Original Research

Mother’s and Father’s Serious Mental Illness and Risk of Child Injury in a Taiwanese Birth Cohort

J Clin Psychiatry 2022;83(6):21m14214

Shiow-Wen Yang, MD, PhD^a,b,c ; Mary A. Kernic, PhD, MPH^d ; Beth A. Mueller, MPH, DrPH^e,f ; Gregory E. Simon, MD, MPH^g ; Kwun-Chuen Gary Chan, PhD^h ; Ann Vander Stoep, PhD^d,i

Original Research

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

J Clin Psychiatry 2022;83(6):21m14185

Li Zhang, MD^a,b,c,d ; Zhiyong Li^a,b,c ; Yu Wu^a,b,c ; Yue Yu, MMed^d,e,f ; Gong-Jun Ji, MD^d,f,g ; Yanghua Tian, MD^d,e,f ; Kai Wang, MD^d,e,f,g

Original Research

Differential Relationships Among C-Reactive Protein, Attention Functioning, and Brain Structure in Bipolar Offspring With and Without Subthreshold Mood Symptoms

J Clin Psychiatry 2022;83(6):21m14113

Wenjin Zou, MD^a,‡ ; Robin Shao, PhD^b,‡ ; Weicong Lu, MD^c ; Ruoxi Zhang, MD^c ; Suk-Yu Yau, PhD^d ; Ningning Chen, MD^c ; Guiyun Xu, PhD, MD^c ; Kwok-Fai So, PhD^e,f ; Kangguang Lin, MD, PhD^c,e

Original Research

Prevalence and Correlates of Obsessive-Compulsive Symptoms in Individuals With Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder

J Clin Psychiatry 2022;83(6):21m14010

Deborah Ahn-Robbins, MSc^a,e ; Nina H. Grootendorst-van Mil, MD, PhD^b ; Chin-Kuo Chang, PhD^a,c,d,e ; David Chandran, PhD^e ; Hitesh Shetty, PhD^e ; Jyoti Sanyal, PhD^e ; James H. MacCabe, FRCPsych, PhD^a,e ; Hannah Cohen, PhD^a,e ; Robert Stewart, MD^a,e ; Frederike Schirmbeck, PhD^f,g ; Lieuwe de Haan, MD, PhD^f,g,‡ ; Richard D. Hayes, PhD^a,e,‡

Original Research

Acceptability of Second-Line Antidepressant Medications Using Filled Prescription Sequences in a Nationwide Cohort Study

J Clin Psychiatry 2022;83(6):21m14248

Thomas Lesuffleur, MSc^b ; Pierre Denis, MSc^b ; Nicolas Hoertel, MD, PhD^c ; Romain Olekhnovitch, PhD^d ; Mark Olfson, MD, PhD^e ; Carlos Blanco, MD, PhD^f ; Frédéric Limosin, MD, PhD^c ; Antoine Rachas, MD, PhD^b ; Philippe Tuppin, MD, PhD^b ; Cédric Lemogne, MD, PhD^a

Original Research

Overlapping Patterns of Suicide Attempts and Non-suicidal Self-Injuries in Adults: A Prospective Clinical Cohort Study

J Clin Psychiatry 2022;83(6):21m14330

Margda Waern, MD, PhD^a,b ; Lotta Strömsten, PhD^c,d ; Stefan Wiktorsson, PhD^a,b ; Bo Runeson, MD, PhD^e ; Ellinor S. Renberg, PhD^d

Original Research

Correlating Psychotropic Use to Major Depressive Disorder and ADHD Research Diagnoses: Trends in a Prospective Pediatric Cohort From Ages 3 to 21

J Clin Psychiatry 2022;83(6):21m14331

Miranda U. Liang, BS ; Natchanan Charatcharungkiat, MD ; Rebecca Tillman, MA ; Hetal M. Patel, MD ; Alecia C. Vogel, MD, PhD ; Joan L. Luby, MD

Original Research

Relationship Between Sporadic Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders: A Study in Families

J Clin Psychiatry 2022;83(6):21m13932

Siham Icho, MD^a,b ; Nicole Korten, PhD^c ; Lianne Reus, MD, PhD^a ; Thijs Belderok, MD^a,d ; Welmoed Krudop, MD, PhD^a,e ; Flora Gossink, MD, PhD^c,f ; Fred van Ruissen, MD, PhD^g ; Petra Cohn-Hokke, MD, PhD^h ; Ricardo Feller, MDⁱ ; John van Swieten, MD, PhD^j ; Annemiek Dols, MD, PhD^c ; Yolande Pijnenburg, MD, PhD^a

Academic Highlights

Expanded Treatment Options and Addressing Unmet Needs in the Diagnosis and Treatment of Bipolar Disorder

J Clin Psychiatry 2022;83(6):MS21058AH5

Joseph F. Goldberg, MD^a ; Melissa P. DelBello, MD, MS^b ; Holly A. Swartz, MD^c

Commentary

Lost in Translation: The Value of Psychiatric Clinical Trials

J Clin Psychiatry 2022;83(6):22com14647

John C. Markowitz, MD^a,b ; Barbara L. Milrod, MD^c

Commentary

Bipolar Disorder and Premenstrual Dysphoric Disorder: Comorbidity Conundrum

J Clin Psychiatry 2022;83(6):22com14573

Teri Pearlstein, MD

Commentary

The Relationship Between Major Depressive Disorder and Multiple Medical Conditions: A Call to Improve Integrated Care Services

J Clin Psychiatry 2022;83(6):22com14600

Rachel A. Weir, MD ; Mark Hyman Rapaport, MD

Commentary

Ketamine in the Real World: Where Do We Go From Here?

J Clin Psychiatry 2022;83(6):22com14648

Samuel T. Wilkinson, MD

Clinical and Practical Psychopharmacology

Practical Psychopharmacology: Using a Knowledge of Pharmacokinetics to More Rapidly Stabilize Patients at Lower Drug Doses

J Clin Psychiatry 2022;83(6):22f14722

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

A Primer on How to Critically Read an Observational Study on Adverse Medical Outcomes Associated With Long-Term Antidepressant Drug Use

J Clin Psychiatry 2022;83(6):22f14733

Chittaranjan Andrade, MD

Case Report

Antidepressant Discontinuation Syndrome Resulting in a Suicide Attempt: A Case Report

J Clin Psychiatry 2022;83(6):22cr14562

Nicholas Waldvogel, BA^a ; Alan Akira, MD^b

Letter to the Editor

Valproate Prescribing Practices in Individuals of Childbearing Age at a Tertiary Care Women’s Hospital

J Clin Psychiatry 2022;83(6):22lr14566

Camille Tastenhoye, MD ; Priyanka Amin, MD ; Allison Imhoff, PharmD ; Priya Gopalan, MD

Letter to the Editor

Addressing the Problem of Prescription of Valproate to Women of Childbearing Age: Reply to Tastenhoye et al

J Clin Psychiatry 2022;83(6):22lr14566a

Chittaranjan Andrade, MD

Volume 83 • 2022 • 6

Editorial

Prescribing Guideline for Valproic Acid and Women of Reproductive Potential: Forget It Exists

Living in a Pharmacologically Imperfect World

Systematic Review

Relationship of Premenstrual Dysphoric Disorder With Bipolar Disorder: A Systematic Review

Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review

A Systematic Review of Fear Learning, Extinction Learning, and Reversal Learning in Obsessive-Compulsive Disorder: Implications for Treatment

Differential Engagement by Race/Ethnicity in Experimental Trials of Mental Health Treatment Interventions: A Systematic Review

Safety of Ketamine Augmentation to Monoamine Oxidase Inhibitors in Treatment-Resistant Depression: A Systematic Literature Review and Case Series

Original Research

Clinical Effectiveness of Intravenous Racemic Ketamine Infusions in a Large Community Sample of Patients With Treatment-Resistant Depression, Suicidal Ideation, and Generalized Anxiety Symptoms: A Retrospective Chart Review

The Economic Burden of Schizophrenia in the United States

Psychiatric Diagnoses Among Transgender and Gender Diverse Patients Compared to Cisgender Patients

Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial

Longitudinal Course of Adverse Events With Esketamine Nasal Spray: A Post Hoc Analysis of Pooled Data From Phase 3 Trials in Patients With Treatment-Resistant Depression

Mother’s and Father’s Serious Mental Illness and Risk of Child Injury in a Taiwanese Birth Cohort

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

Differential Relationships Among C-Reactive Protein, Attention Functioning, and Brain Structure in Bipolar Offspring With and Without Subthreshold Mood Symptoms

Prevalence and Correlates of Obsessive-Compulsive Symptoms in Individuals With Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder

Acceptability of Second-Line Antidepressant Medications Using Filled Prescription Sequences in a Nationwide Cohort Study

Overlapping Patterns of Suicide Attempts and Non-suicidal Self-Injuries in Adults: A Prospective Clinical Cohort Study

Correlating Psychotropic Use to Major Depressive Disorder and ADHD Research Diagnoses: Trends in a Prospective Pediatric Cohort From Ages 3 to 21

Relationship Between Sporadic Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders: A Study in Families

Academic Highlights

Expanded Treatment Options and Addressing Unmet Needs in the Diagnosis and Treatment of Bipolar Disorder

Commentary

Lost in Translation: The Value of Psychiatric Clinical Trials

Bipolar Disorder and Premenstrual Dysphoric Disorder: Comorbidity Conundrum

The Relationship Between Major Depressive Disorder and Multiple Medical Conditions: A Call to Improve Integrated Care Services

Ketamine in the Real World: Where Do We Go From Here?

Clinical and Practical Psychopharmacology

Practical Psychopharmacology: Using a Knowledge of Pharmacokinetics to More Rapidly Stabilize Patients at Lower Drug Doses

A Primer on How to Critically Read an Observational Study on Adverse Medical Outcomes Associated With Long-Term Antidepressant Drug Use

Case Report

Antidepressant Discontinuation Syndrome Resulting in a Suicide Attempt: A Case Report

Letter to the Editor

Valproate Prescribing Practices in Individuals of Childbearing Age at a Tertiary Care Women’s Hospital

Addressing the Problem of Prescription of Valproate to Women of Childbearing Age: Reply to Tastenhoye et al

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