The Journal of
Clinical Psychiatry

Volume 86 • 2025 • 1

Editorial

A Collaborative Endeavor

J Clin Psychiatry 2025;86(1):24ed15761

Marlene P. Freeman, MD

Consensus Statement

Synopsis of the 2023 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline for the Management of Bipolar Disorder

J Clin Psychiatry 2025;86(1):24cs15546

Michael J. Ostacher, MD, MPH, MMSc ; Christopher J. Miller, PhD ; Amanda Edwards-Stewart, PhD ; Paulette T. Cazares, MD ; Richard R. Owen, MD ; Matthew A. Fuller, PharmD ; David Osser, MD ; Thad E. Abrams, MD ; Jed P. Mangal, MD ; Ira Katz, MD, PhD ; Jennifer M. Ballard-Hernandez, DNP ; Sarah D. Davis-Arnold, MSN ; Isabella Alvarez, MSN ; James L. Sall, PhD

Systematic Review

Therapeutic Efficacy and Safety of Memantine for Children and Adults With ADHD With a Focus on Glutamate-Dopamine Regulation: A Systematic Review

J Clin Psychiatry 2025;86(1):24r15507

Won-Seok Choi, MD, PhD ; Sheng-Min Wang, MD, PhD ; Young Sup Woo, MD, PhD ; Won-Myong Bahk, MD, PhD

Systematic Review

Inpatient Treatment of Suicidality: A Systematic Review of Clinical Trials

J Clin Psychiatry 2025;86(1):24r15382

Ali Abdolizadeh, MSc ; Brett D. M. Jones, MD, MSc ; Maryam Hosseini Kupaei, HBSc ; Amal Shah, HBSc ; Terri Rodak, MA, MISt ; Salman Farooqui, HBSc ; Mohammed Omair Husain, MBBS, MRCPsych ; Cory R. Weissman, MD ; Juveria Zaheer, MD, MSc ; David Gratzer, MD ; Daniel M. Blumberger, MD, MSc ; Muhammad Ishrat Husain, MBBS, MD (Res.), MRCPsych

Original Research

Treatments and Treatment Predictors in Patients With Substance Use Disorders and Comorbid Attention-Deficit/Hyperactivity Disorder: First Results From the International Naturalistic Cohort Study of ADHD and SUD (INCAS)

J Clin Psychiatry 2025;86(1):24m15494

Christoffer Brynte, MD, PhD ; Arnt Schellekens, MD, PhD ; Csaba Barta, PhD ; Alex H. Abraham Begeman, MA ; Cleo L. Crunelle, MD, PhD, PhD ; Costanza Daigre, PhD ; Zsolt Demetrovics, PhD ; Geert Dom, PhD ; Lara Grau-López, MD, PhD ; Mariely Hernandez, PhD ; Romain Icick, MD, PhD ; Brian Johnson, MD, PhD ; Máté Kapitány-Fövény, PhD ; Michiel van Kernebeek, MD ; Maija Konstenius, PhD ; Frances R. Levin, MD ; Mathias Luderer, MD, PhD ; Frieda Matthys, MD, PhD ; Franz Moggi, PhD ; J. Antoni Ramos-Quiroga, MD, PhD ; Laura Schleussner, MD ; Norman Therribout, MA ; Anil Thomas, MD ; Florence Vorspan, MD, PhD ; Wim van den Brink, MD, PhD ; Johan Franck, MD, PhD

Original Research

Long-Term Safety, Tolerability, and Durability of Treatment Effect of Olanzapine and Samidorphan: Results of a 4-Year Open-Label Study

J Clin Psychiatry 2025;86(1):24m15511

Jacob S. Ballon, MD, MPH ; René S. Kahn, MD, PhD ; Christina Arevalo, MS ; Martin Dunbar, PhD ; David McDonnell, MD ; Christoph U. Correll, MD

Original Research

Racial Disparities in Mood Stabilizer Prescribing in Mania in Nonpsychotic, Hospitalized Patients With Bipolar I Disorder

J Clin Psychiatry 2025;86(1):24m15524

Farah Khorassani, PharmD, BCPP ; Nana Entsuah-Boateng, PharmD ; Michael Sayer, PharmD, PhD ; Aya Ozaki, BSPharm, PharmD

Original Research

Association Between Suicidal Behaviors and Obstructive Sleep Apnea Based on the STOP-Bang Questionnaire: A Nationwide Population-Based Study

J Clin Psychiatry 2025;86(1):24m15345

Chang Hoon Han, MD, PhD ; Joohyng Son, MD ; Jae Ho Chung, MD, PhD

Original Research

Psychological Support Approaches in Psychedelic Therapy: Results From a Survey of Psychedelic Practitioners

J Clin Psychiatry 2025;86(1):24m15521

David A. Bender, MD ; Sandeep M. Nayak, MD ; Joshua S. Siegel, MD, PhD ; David J. Hellerstein, MD ; Baris C. Ercal, MD, PhD ; Eric J. Lenze, MD

Original Research

Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study

J Clin Psychiatry 2025;86(1):24m15438

Maurizio Fava, MD ; Luca Pani, MD ; Sara De Martin, PhD ; Andrew J. Cutler, MD ; Charles W. Gorodetzky, MD, PhD ; Frank J. Vocci, PhD ; Frank L. Sapienza, MS ; Thomas R. Kosten, MD ; Cornelia Kröger, PhD ; Paggard Champasa, PhD ; Clotilde Guidetti, MD ; Stefano Comai, PhD ; Andrea Mattarei, PhD ; Franco Folli, MD ; David Bushnell, MS ; Sergio Traversa, PharmD ; Charles E. Inturrisi, PhD ; Paolo L. Manfredi, MD ; Marco Pappagallo, MD

Original Research

Sequencing Stimulant Medication and Behavioral Parent Training in Multiplex ADHD Families: A Pilot SMART

J Clin Psychiatry 2025;86(1):24m15463

Joyce H. L. Lui, PhD ; Andrea Chronis-Tuscano, PhD ; Daniel Almirall, PhD ; Kathryn B. Whitlock, MS ; William French, MD ; Mark A. Stein, PhD

Original Research

Brexpiprazole in Combination With Sertraline and as Monotherapy in Posttraumatic Stress Disorder: A Full-Factorial Randomized Clinical Trial

J Clin Psychiatry 2025;86(1):24m15577

Mary Hobart, PhD ; Denise Chang, PhD ; Nanco Hefting, MSc ; Lori L. Davis, MD

Original Research

Safety and Tolerability of Xanomeline and Trospium Chloride in Schizophrenia: Pooled Results From the 5-Week, Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials

J Clin Psychiatry 2025;86(1):24m15497

Inder Kaul, MD ; Amy Claxton, PhD ; Sharon Sawchak, RN ; Colin Sauder, PhD ; Stephen K. Brannan, MD ; Edwin Raj, PhD ; Shiling Ruan, PhD ; George Konis, MD ; David Brown, MD ; Andrew J. Cutler, MD ; Ronald Marcus, MD

Estimating the 12-Hour Serum Lithium Level (eLi<sub data-src=

12): Development and Two Proof-of-Concept Studies">

Original Research

Estimating the 12-Hour Serum Lithium Level (eLi₁₂): Development and Two Proof-of-Concept Studies

J Clin Psychiatry 2025;86(1):24m15547

Ole Köhler-Forsberg, MD, PhD, DMSc ; Anne Christine Wiuff, MD ; Torben A. Devantier, MD, PhD ; Søren D. Østergaard, MD, PhD ; Stephen V. Faraone, PhD ; Andrew A. Nierenberg, MD

Original Research

Results From a Long-Term Observational Follow-Up Study of a Single Dose of Psilocybin for a Treatment-Resistant Episode of Major Depressive Disorder

J Clin Psychiatry 2025;86(1):24m15449

Guy M. Goodwin, MD ; Ania Nowakowska, MSc ; Merve Atli, MSc ; Boadie W. Dunlop, MD ; David Feifel, MD, PhD ; David J. Hellerstein, MD ; Lindsey Marwood, PhD ; Zainib Shabir, MSc ; Sunil Mistry, MSc ; Susan C. Stansfield, PhD ; Emma Teoh, MSc ; Joyce Tsai, PhD ; Matthew B. Young, PhD ; Ekaterina Malievskaia, MD

Original Research

Clinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study

J Clin Psychiatry 2025;86(1):24m15399

Radhika Kelkar, MD ; George C. Liu, MD ; Michelle S. Goodman, PhD ; Abdullah Al-Hashemi, MD ; Taeho Greg Rhee, PhD ; Daniel M. Blumberger, MD, MSc ; Tyler S. Kaster, MD, PhD

Original Research

Esketamine Nasal Spray vs Quetiapine Extended-Release: Examining Work Productivity Loss and Related Costs in Patients With Treatment-Resistant Depression

J Clin Psychiatry 2025;86(1):24m15425

Kristin Clemens, DNP, PMHNP-BC, MSN ; Amanda Teeple, DrPH ; Maryia Zhdanava, MA ; Aditi Shah, MA ; Kruti Joshi, MPH ; Jozefien Buyze, PhD ; Dominic Pilon, MA ; Hannah E. Bowrey, PhD ; Yordan Godinov, MD

Original Research

Psychological Challenges of Adults With Severe Mental Illness During the COVID-19 Pandemic

J Clin Psychiatry 2025;86(1):24m15448

Kadiatou Diallo-Montford, DrPH, MPH ; Jessica S. Schwind, PhD ; Stacy W. Smallwood, PhD ; Amenah Qotineh, MSc ; Kelly L. Sullivan, PhD

Original Research

Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial

J Clin Psychiatry 2025;86(1):24m15272

Jing Huang, MD ; AnMei Chen, MS ; Hua Jin, MD ; Fangkun Liu, MD ; Gangrui Hei, MD, PhD ; Ziwei Teng, MD ; Jingmei Xiao, MD ; Renrong Wu, MD, PhD ; Jingping Zhao, MD, PhD ; John M. Davis, MD ; Ping Shao, MD, PhD ; Robert C. Smith, MD, PhD

Original Research

Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial

J Clin Psychiatry 2025;86(1):24m15523

Jennifer B. Dwyer, MD, PhD ; Christian Schmahl, MD ; Manabu Makinodan, MD, PhD ; Sarah K. Fineberg, MD, PhD ; Stephanie Sommer, PhD ; Jan Wruck, MS ; Ante Jelaska, MD ; Abidemi Adeniji, PhD ; Marianne Goodman, MD

Original Research

Baseline Cardiovascular Risk Factors in Patients With Severe Mental Illness (SMI) and Second Generation Antipsychotic Use From the Fixed Dose Intervention Trial of New England Enhancing Survival in SMI (FITNESS)

J Clin Psychiatry 2025;86(1):24m15392

Virginie-Anne Chouinard, MD ; Mary Price, MA ; Sophie Forte, NP ; Steven Prete, RN ; Hadley Heinrich, BA ; Samantha N. Smith, BS ; Vicki Fung, PhD ; John Hsu, MD ; Dost Ongur, MD, PhD

Original Research

Effects of Intravenous Hydroxyzine Versus Haloperidol Monotherapy for Delirium: A Retrospective Study

J Clin Psychiatry 2025;86(1):24m15569

Kaoruhiko Kubo, MD ; Moe Takehara ; Mayuko Hirata ; Sunjun Huh ; Sayoko Kawano, PhD ; Hiroyuki Uchida, MD, PhD ; Hiroyoshi Takeuchi, MD, PhD

Original Research

Olanzapine/Samidorphan Effects on Weight Gain: An Individual Patient Data Meta-Analysis of Phase 2 and 3 Randomized Double-Blind Studies

J Clin Psychiatry 2025;86(1):24m15526

Christoph U. Correll, MD ; Michael J. Doane, PhD ; David McDonnell, MD ; Sarah Akerman, MD ; Stephen R. Saklad, PharmD, BCPP

Original Research

Geographical and Socioeconomic Disparities in Substance and Opioid Use Disorders Among Inflammatory Bowel Disease Hospitalizations in the United States From the National Inpatient Sample

J Clin Psychiatry 2025;86(1):24m15339

Jin S. Kim, MD ; Patrick W. Chang, MD ; Jason Hung, MS ; Hohui E. Wang, MD ; Mu-Hong Chen, MD, PhD ; Sarah Sheibani, MD ; Florence-Damilola Odufalu, MD ; Jennifer L. Dodge, MPH ; Bing Zhang, MD, MAS

Commentary

The Opioid Industryʼs Legacy: A Generation of Prescribed Suffering

J Clin Psychiatry 2025;86(1):24com15664

Andrew Kolodny, MD ; Robert M. Bohler, PhD, MPH

Commentary

Fluctuating Impairment and Complex Presentations: Evolving Care and Research Priorities in ADHD

J Clin Psychiatry 2025;86(1):24com15705

Craig Surman, MD ; Timothy Wilens, MD

Commentary

A New Tool to Refine Lithium Therapy: A Simple Formula for a Complex Problem

J Clin Psychiatry 2025;86(1):24com15743

Gin S. Malhi, MBChB, BSc(Hons), MSt, MD ; Erica Bell, BSc ; Kinga Szymaniak, PsyM, PhD

Commentary

Understanding the Tolerability Profile of Xanomeline-Trospium Combination for the Treatment of Schizophrenia

J Clin Psychiatry 2025;86(1):25com15775

Leslie Citrome, MD, MPH

Clinical and Practical Psychopharmacology

Maternal Cannabis Use in Pregnancy and Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder in Offspring

J Clin Psychiatry 2025;86(1):24f15717

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Target Trial Emulation: A Concept Simply Explained

J Clin Psychiatry. 2025;86(1):25f15796.

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Maternal Cannabis Use During Pregnancy and Neuropsychiatric Adverse Outcomes During Childhood and Early Adult Life

J Clin Psychiatry 2025;86(1):24f15753

Chittaranjan Andrade, MD

ASCP Corner

Relationship Between Trauma, PTSD, and Schizophrenia: Relevance for Outcomes, Screening, and Interventions

J Clin Psychiatry 2025;86(1):24ac15773

Julieta Ramirez, MD ; Christoph U. Correll, MD

Brief Report

Sex Differences in PTSD Among US Military Veterans: Role of Trauma, Coping, and Social Factors

J Clin Psychiatry 2025;86(1):24br15621

Rick Yang, HSD ; Ian C. Fischer, PhD ; Peter J. Na, MD, MPH ; Carolyn M. Mazure, PhD ; Robert H. Pietrzak, PhD, MPH

Brief Report

Ketamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data?

J Clin Psychiatry 2025;86(1):24br15655

Taeho Greg Rhee, PhD ; Sung Ryul Shim, PhD ; Pasha A. Davoudian, BA, MPhil ; Randall T. Espinoza, MD, MPH ; Roger S. McIntyre, MD

Brief Report

Suicides by Sodium Nitrite Reported to America’s Poison Centers: 2020–2023

J Clin Psychiatry 2025;86(1):24br15678

Anita Mudan, MD ; Jacob A. Lebin, MD

Letter to the Editor

Opioid Use Disorder in Sexually and Gender Diverse Populations: Can We Do Better?

J Clin Psychiatry 2025;86(1):24lr15751

Margaret Chaplin, MD ; Katie Rogers, PA-S ; Vania Modesto-Lowe, MD, MPH

Correction

Correction. Ketamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data?

J Clin Psychiatry 2025;86(1):25lcx15827

Volume 86 • 2025 • 1

Editorial

A Collaborative Endeavor

Consensus Statement

Synopsis of the 2023 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline for the Management of Bipolar Disorder

Systematic Review

Therapeutic Efficacy and Safety of Memantine for Children and Adults With ADHD With a Focus on Glutamate-Dopamine Regulation: A Systematic Review

Inpatient Treatment of Suicidality: A Systematic Review of Clinical Trials

Original Research

Treatments and Treatment Predictors in Patients With Substance Use Disorders and Comorbid Attention-Deficit/Hyperactivity Disorder: First Results From the International Naturalistic Cohort Study of ADHD and SUD (INCAS)

Long-Term Safety, Tolerability, and Durability of Treatment Effect of Olanzapine and Samidorphan: Results of a 4-Year Open-Label Study

Racial Disparities in Mood Stabilizer Prescribing in Mania in Nonpsychotic, Hospitalized Patients With Bipolar I Disorder

Association Between Suicidal Behaviors and Obstructive Sleep Apnea Based on the STOP-Bang Questionnaire: A Nationwide Population-Based Study

Psychological Support Approaches in Psychedelic Therapy: Results From a Survey of Psychedelic Practitioners

Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study

Sequencing Stimulant Medication and Behavioral Parent Training in Multiplex ADHD Families: A Pilot SMART

Brexpiprazole in Combination With Sertraline and as Monotherapy in Posttraumatic Stress Disorder: A Full-Factorial Randomized Clinical Trial

Safety and Tolerability of Xanomeline and Trospium Chloride in Schizophrenia: Pooled Results From the 5-Week, Randomized, Double-Blind, Placebo-Controlled EMERGENT Trials

Estimating the 12-Hour Serum Lithium Level (eLi12): Development and Two Proof-of-Concept Studies

Results From a Long-Term Observational Follow-Up Study of a Single Dose of Psilocybin for a Treatment-Resistant Episode of Major Depressive Disorder

Clinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study

Esketamine Nasal Spray vs Quetiapine Extended-Release: Examining Work Productivity Loss and Related Costs in Patients With Treatment-Resistant Depression

Psychological Challenges of Adults With Severe Mental Illness During the COVID-19 Pandemic

Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial

Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial

Baseline Cardiovascular Risk Factors in Patients With Severe Mental Illness (SMI) and Second Generation Antipsychotic Use From the Fixed Dose Intervention Trial of New England Enhancing Survival in SMI (FITNESS)

Effects of Intravenous Hydroxyzine Versus Haloperidol Monotherapy for Delirium: A Retrospective Study

Olanzapine/Samidorphan Effects on Weight Gain: An Individual Patient Data Meta-Analysis of Phase 2 and 3 Randomized Double-Blind Studies

Geographical and Socioeconomic Disparities in Substance and Opioid Use Disorders Among Inflammatory Bowel Disease Hospitalizations in the United States From the National Inpatient Sample

Commentary

The Opioid Industryʼs Legacy: A Generation of Prescribed Suffering

Fluctuating Impairment and Complex Presentations: Evolving Care and Research Priorities in ADHD

A New Tool to Refine Lithium Therapy: A Simple Formula for a Complex Problem

Understanding the Tolerability Profile of Xanomeline-Trospium Combination for the Treatment of Schizophrenia

Clinical and Practical Psychopharmacology

Maternal Cannabis Use in Pregnancy and Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder in Offspring

Target Trial Emulation: A Concept Simply Explained

Maternal Cannabis Use During Pregnancy and Neuropsychiatric Adverse Outcomes During Childhood and Early Adult Life

ASCP Corner

Relationship Between Trauma, PTSD, and Schizophrenia: Relevance for Outcomes, Screening, and Interventions

Brief Report

Sex Differences in PTSD Among US Military Veterans: Role of Trauma, Coping, and Social Factors

Ketamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data?

Suicides by Sodium Nitrite Reported to America’s Poison Centers: 2020–2023

Letter to the Editor

Opioid Use Disorder in Sexually and Gender Diverse Populations: Can We Do Better?

Correction

Correction. Ketamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data?

Celebrating85 Years

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Estimating the 12-Hour Serum Lithium Level (eLi₁₂): Development and Two Proof-of-Concept Studies

Celebrating
85 Years

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more articles