Clozapine-Induced Eosinophilia: Subsequent Neutropenia and Corresponding Allergic Mechanisms

Sir: Galletly et al. describe a patient treated with clozapine who had severe eosinophilia (55% of WBCs) followed by neutropenia (neutrophil count of 1840/μL) 7 days later. We report a similar case of a clozapine-treated patient who developed eosinophilia (47% of WBCs) and subsequent neutropenia (neutrophil count of 1800/μL) 6 days later.