The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

The Journal of
Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Metabolic Syndrome in Offspring of Bipolar Parents
Original Research

July 1, 2024

In offspring of parents with bipolar disorder, lower socioeconomic status and personal history of mood disorders were associated with greater risk of metabolic syndrome and its components.
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JCP
Suicidal Status, Inflammation, and Resting-State Activity in MDD
Original Research

June 26, 2024

Resting-state activity of the VLPFC was altered in suicide attempters, possibly contributing to language impairment and poor decision-making and cognitive control.
, , , et al
JCP
Immune Targeted Therapies for Depression: Antidepressant Effects of Monoclonal Antibodies
Narrative Review

June 24, 2024

Immune dysregulation may contribute to treatment resistance in depression. Monoclonal antibodies have shown promise in treating depression when used for inflammatory disorders and may offer new hope for patients…
, , , et al
JCP
Depression, Rumination, and Suicide Attempts in Adolescents With Mood Disorders: Sex Differences
Original Research

June 19, 2024

The authors found that in male adolescents, suicide attempts are mostly influenced by depressive symptoms. In female adolescents, depressive symptoms not only directly increase the risk of suicide attempts,…
, , , et al
JCP
Focus on Women’s Mental Health: Twenty Years and Counting
Editorial

June 17, 2024

On the anniversary of JCP’s Focus on Women’s Mental Health section, Marlene P. Freeman reflects on the past 20 years in women’s mental health care, including what has changed…
JCP
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
Original Research

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
, , , et al
JCP
Cigarette Smoking and Tobacco Use Disorder Among US Adults
Original Research

June 12, 2024

The prevalence of daily smoking with tobacco use disorder (TUD) was 10 times that of daily cigarette smoking without TUD. But even nondaily smoking can produce or sustain TUD,…
, , , et al
JCP
Pharmacogenetic Phenotypes in a Perinatal Mental Health Clinic
Original Research

June 10, 2024

In patients of childbearing age who have had atypical responses or side effects to antidepressants, pharmacogenomic testing may be considered to guide dose or choice of agent. Dose adjustments…
, , , et al
JCP
Extreme Dysphoria of Pregnancy: A Distinct Syndrome Warranting Attention?
Commentary

June 10, 2024

Dr Freeman discusses the understudied phenomenon of pregnancy-related extreme dysphoria or depression, distinct from typical major depressive episodes. Three illustrative case vignettes are presented.
JCP
Why Ask Patients to Cut Into Quarters 10 mg THC Gummies From a Dispensary When 2.5 mg THC Is Available by Prescription?
Letter to the Editor

June 5, 2024

The authors discuss a study by Sawicki et al of dementia patients for whom 2.5 mg of THC was recommended for neuropsychiatric symptoms.
,
JCP
Accounting for Differences in Incident Guideline Discordant Prescribing for PTSD Among Women and Men Veterans
Original Research

June 5, 2024

Women Veterans with PTSD were 67% more likely to initiate a guideline discordant medication. More than half of this effect was explained by bipolar disorder, age, and prior psychiatric…
, , , et al
JCP
Epilepsy, Antiepileptic Drugs, and Adverse Pregnancy Outcomes, 1: Recent Research
Clinical and Practical Psychopharmacology

June 5, 2024

This article provides women who have epilepsy and who use antiepileptic drugs during pregnancy with information about the many risks to which they and their fetus/neonate are exposed at…

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