Reply to Letter to the Editor "Safety of Sildenafil for Antidepressant-Related Sexual Dysfunction"

Letter to the Editor

Sir: We read with interest the letter from Dr. Pies. The cytochrome P450 enzyme system is certainly an important factor to consider in prescribing all medications. There may be some disagreement, however, in how strongly, and with what clinical significance, nefazodone inhibits the CYP3A4 enzyme.