The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

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Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Original Research

February 19, 2025

In this 10-week study, brexpiprazole in combination with sertraline, but not as monotherapy, demonstrated the potential to be a new efficacious treatment for PTSD.
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JCP
Original Research

February 19, 2025

Combination treatment may be helpful for most multiplex ADHD families, and sequencing treatments with behavioral parent training first followed by stimulant medication for the mother may be the most…
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JCP
Semaglutide-Induced Euphoria in a Patient With Bipolar Disorder
Case Report

February 17, 2025

A 77-year-old woman with bipolar disorder experienced transient euphoria following semaglutide use for obesity.
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Vol 85 • 2024 • Number 4

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Meta-Analysis

Changes in Cognition in Patients With Schizophrenia

Systematic Review

Diagnostic Assessment via Telehealth vs Face-to-Face

Original Research

Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans

Original Research

Bridge Symptoms Between Borderline Personality and PTSD

Original Research

Gepirone-ER and Sexual Function in Patients with MDD

Original Research

Medication Use and Lines of Treatment in Patients With Insomnia Disorder
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Focus on Psychosis Focus on Geriatric Psychiatry Focus on Women’s Mental Health Focus on Suicide Early Career Psychiatrists Focus on Psychotherapy

Original Research

JCP
Long-Term Safety and Efficacy of Esmethadone in MDD
Original Research

February 17, 2025

A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
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JCP
Psychological Support in Psychedelic Therapy
Original Research

February 5, 2025

The survey reveals differences of opinion among psychedelic researchers, with a slight trend toward preference for an emotive approach to psychological support.
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JCP
Suicidal Behaviors and Obstructive Sleep Apnea
Original Research

February 3, 2025

Based on findings from the STOP-Bang questionnaire, suicidal behaviors may be more common in patients with obstructive sleep apnea (OSA) than in those without OSA.
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Review Articles

JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
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JCP
Cognitive Effects of ECT in Schizophrenia: A Review
Review Article

June 5, 2024

ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
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JCP
Interpersonal Psychotherapy for PTSD: A Critical Review
Review Article

May 29, 2024

This critical review will give clinicians confidence in considering IPT as an alternative to exposure treatments for posttraumatic stress disorder.
JCP
Omega-3 PUFA Supplements for ADHD
Meta-Analysis

August 30, 2023

Although omega-3 polyunsaturated fatty acids (PUFAs) may not improve core symptoms of attention-deficit/hyperactivity disorder, longer-term PUFA supplementation may have potential benefits.
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JCP
Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Brain Imaging Research
Meta-Analysis

March 27, 2023

Different brain regions were changed with psychotherapy versus medication. The findings may help with predicting treatment efficacy and identifying treatment biomarkers in these disorders.
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JCP
Antipsychotic Dose and Weight Gain
Meta-Analysis

February 8, 2023

Although effects on weight gain have been explored for several antipsychotics, the role of dose in producing these effects has not been widely studied. This meta-analysis examined the association…
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Read articles from ASCP Corner

ASCP Corner

Letters to the Editor

JCP
The Need for Clinical Guidance on Ketamine/Esketamine Use in Clinical Settings
Letter to the Editor

February 5, 2025

The authors comment on a recent study by Santucci et al.
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JCP
Opioid Use Disorder in Sexually and Gender Diverse Populations: Can We Do Better?
Letter to the Editor

February 3, 2025

The authors respond to a recent JCP article by McDowell and colleagues.
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JCP
Mental Health Assessment and Psychosocial Intervention in Maternal-Fetal Interventions
Letter to the Editor

November 18, 2024

In discussing a recent JCP letter to the editor, Akerson et al recommend that centers for fetal diagnosis and treatment include a social worker who can provide psychosocial assessment,…
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JCP
Clarification Regarding the Psychiatrist’s Role—Reply to Akerson et al
Letter to the Editor

November 18, 2024

The authors respond to a letter by Akerson et al.
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JCP
Detecting Misuse of Prescription Opioids
Letter to the Editor

October 21, 2024

The authors discuss the difficulty in screening for opioid misuse and the need for clinicians to gain confidence in initiating difficult discussions with patients on long-term opioid treatment.
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JCP
Mental Health Assessments for Fetal Interventions
Letter to the Editor

June 24, 2024

The authors offer guidance and raise awareness about the intersection of maternal mental health and fetal interventions.
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Commentaries

JCP
Evolving Care and Research Priorities in ADHD
Commentary

December 23, 2024

Surman and Wilens discuss two recent JCP articles highlighting that how ADHD manifests can be heavily influenced by context, as well as individual vulnerabilities and strengths.
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JCP
The Opioid Industry's Legacy: A Generation of Prescribed Suffering
Commentary

December 18, 2024

The authors discuss the influential and far-reaching effects of messaging from the opioid industry on the opioid use epidemic.
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JCP
SUD Programs for Transgender and Gender Diverse Patients
Commentary

November 11, 2024

The authors discuss responsiveness of transgender and gender diverse patients to SUD treatment at different care levels (eg, outpatient, residential, inpatient), as well as how to reduce stressors and…
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JCP
Clinical Implications of Adult ADHD: What New Data Tell Us
Commentary

October 10, 2024

The authors discuss striking new findings from the Morbidity and Mortality Weekly Report on the burden of adult ADHD, demonstrating the need for the upcoming APSARD Adult ADHD Guidelines.
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JCP
Reproductive Pharmacovigilance and Best Practices
Commentary

August 26, 2024

Dr Freeman discusses a recent study by Pacilio et al that characterized real world practices around ketamine treatment and pregnancy testing, consent processes, and contraception use. She emphasizes the…
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.

More JCP Articles

JCP
Target Trial Emulation: A Concept Simply Explained
Clinical and Practical Psychopharmacology

February 12, 2025

Target trial emulation can address study objectives that, for ethical or logistic reasons, cannot easily be examined in RCTs. Read this article to learn about the methodology and explore…
JCP
Correction

February 11, 2025

JCP
Racial Disparities in Mood Stabilizer Prescribing in Mania
Original Research

February 3, 2025

Significant disparities in prescription rates of valproic acid and lithium were observed, with Black patients more likely to receive valproic acid and less likely to receive lithium compared to…
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JCP
Relationship Between Trauma, PTSD, and Schizophrenia
ASCP Corner

January 29, 2025

The authors summarize the clinical relevance of trauma and PTSD in patients with schizophrenia and examine assessment and treatment options of trauma and related conditions to consider when treating…
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JCP
ECT for Psychotic vs Nonpsychotic Depression
Original Research

January 29, 2025

Patients with major depression with psychotic features had higher response rates to ECT than those without psychotic features and similar rates of adverse cognitive effects. After adjustment for confounders,…
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JCP
A Collaborative Endeavor
Editorial

January 29, 2025

JCP’s Editor in Chief thanks reviewers, editorial board members, and editors for their contributions to the journal over the past year.
JCP
Ketamine vs ECT in the Management of Treatment-Resistant Depression: Do We Need More Data?
Brief Report

January 27, 2025

Data suggest the difference between ketamine and ECT in efficacy for treatment-resistant depression may be smaller than previously thought.
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JCP
Esketamine Nasal Spray vs Quetiapine ER in Treatment-Resistant Depression
Original Research

January 27, 2025

Esketamine was associated with significantly larger improvements in work productivity loss and related costs compared to quetiapine, suggesting greater benefits from patient well-being and employer perspectives.
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JCP
Psychological Challenges of Adults with SMI during the COVID-19 Pandemic
Original Research

January 22, 2025

Adults with SMI diagnosed with COVID-19 and those who sheltered in place during lockdown experienced more severe psychological distress compared to those not diagnosed with COVID-19.
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JCP
Suicides by Sodium Nitrite Reported to US Poison Centers
Brief Report

January 22, 2025

During 2020-2023, the number of sodium nitrate exposure cases peaked at 39 in 2022, with a drop to 29 in 2023. Case fatality was 41.5%.
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JCP
Sulforaphane Added to Antipsychotics for Negative Symptoms of Schizophrenia
Original Research

January 20, 2025

Add-on high dose sulforaphane may reduce negative symptoms in patients with schizophrenia, although the clinical significance of this reduction needs further evaluation.
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JCP
Synopsis of the VA/DOD Clinical Practice Guideline for Management of Bipolar Disorder
Consensus Statement

January 13, 2025

This synopsis focuses on clinically relevant recommendations related to identification and management of bipolar disorder, including the acute and maintenance phases of illness.
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