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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Shared Possession Trance Disorder in 4 Children
Case Report

May 28, 2026

Four children from the same household experienced recurrent fainting episodes accompanied by changes in speech, facial expression, and mannerisms.
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PCC
Ventilation Weaning, Anxiety, and Valproic Acid
Case Report

May 28, 2026

The authors present the case of a man with Guillan Barre syndrome, whose mechanical ventilation weaning was prolonged, in part, by anxiety.
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PCC
Scrambler Therapy for Neuropathic Pain
Case Report

May 26, 2026

Scrambler therapy is an innovative treatment option for patients with chronic neuropathic pain, especially for those who do not respond to conventional interventions.
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PCC
Lorazepam vs. Diazepam in AUD
Original Research

May 26, 2026

Both lorazepam and diazepam led to more than 50% reduction in Clinical Institute Withdrawal Assessment for Alcohol–Revised scores within 5 days of initiation of treatment in alcohol dependence syndrome.
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PCC
Alcohol Use Disorders in Primary Care
Rounds in the General Hospital

May 21, 2026

Patients with major depressive disorder and a comorbid AUD often present with more severe manifestations, including thoughts of suicide, co-occurring personality disorders, and higher rates of smoking.
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PCC
ECT for Psychosis in Huntington Disease-Like 2
Case Report

May 19, 2026

A 47-year-old woman with genetically confirmed Huntington disease-like 2 had refractory psychosis and functional decline but responded well to electroconvulsive therapy.
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Figure—Journal cover summarizes articles on alcohol craving, insomnia, antidepressant monitoring, autism, and lithium use.

Vol 28 • 2026 • Number 2

Read the Current Issue

Original Research

Alcohol Craving and Mood Disorders

Original Research

Ultra–Low-Dose Mirtazapine for Chronic Insomnia

Original Research

Antidepressant Monitoring Referrals to Higher-Level Services

Meta-Analysis

Role of tDCS in Autism

Narrative Review

Lithium in Mood and Bipolar Disorders

Rounds in the General Hospital

Strategies for Managing Dyspnea
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Readability of Self-Reported Psychosis Measures
Original Research

May 5, 2026

Most psychosis self-report measures are written above recommended reading levels, reducing accessibility for many patients with cognitive, educational, or symptomatic limitations.
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PCC
SUD Referrals Among SMI Inpatients and the NHHSRA
Original Research

March 31, 2026

This study evaluates the performance of the New Hampshire Hospital Screening and Referral Algorithm and describes the characteristics of inpatients with serious mental illness referred for substance use disorder…
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PCC
Attitudes of ED Nurses Toward Violent Patients
Original Research

March 26, 2026

Staff attitudes significantly influence aggression management, with over half of surveyed nurses holding neutral—not positive—views on causes and management.
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Review Articles

PCC
MiRNAs as Biomarkers in Neuropsychiatric Disorders
Narrative Review

April 30, 2026

This review highlights how microRNA dysregulation can shed light on the molecular mechanisms underlying neuropsychiatric disorders and serve as potential biomarkers for early diagnosis and prognosis.
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PCC
Gender-Affirming Surgery, Gender Dysphoria, and QOL
Review Article

November 11, 2025

Those who receive gender dysphoria treatment at a younger age may experience lower rates of suicidal ideation, underscoring potential mental health benefits of timely intervention.
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PCC
Improving Community Mental Health Care
Narrative Review

October 9, 2025

This review highlights critical areas for enhancing the quality and sustainability of community mental health services.
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PCC
Precision Psychiatry for Depression Treatment
Narrative Review

September 9, 2025

Novel precision medicine tools in depression aim to identify the optimal treatment for each patient and have the potential to significantly improve depression management by guiding treatment selection for…
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PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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PCC
Climate Change and Mental Health
Review Article

July 24, 2025

This scoping review highlights the significant impact of climate change on mental health in India, particularly among individuals from lower socioeconomic backgrounds in rural areas.
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Rounds in the General Hospital

PCC
Manifestations Associated With CNS Lesions
Rounds in the General Hospital

May 19, 2026

Neuropsychiatric manifestations of brain metastases are varied, although certain symptoms can be associated with the brain region in which there is a metastasis; lesions that affect certain parts of…
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PCC
Differentiating Bipolar and Other Psychiatric Disorders
Rounds in the General Hospital

May 12, 2026

Diagnosis of bipolar spectrum disorder is often complicated, as most patients present for care during depressive episodes, which are more frequent than hypomanic or manic episodes.
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PCC
Strategies for Documenting the Medical Record
Rounds in the General Hospital

May 7, 2026

Documentation should be objective and relevant, especially in psychosocially complex cases—too much information can interfere with establishing the correct diagnosis and treatment plan, while too little increases risk of…
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PCC
How to Document Complex Cases
Rounds in the General Hospital

April 9, 2026

Case presentations often drive differential diagnosis creation by what is said (and not said) and by whether information given is the “lead” or merely a (potentially interesting) tidbit.
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PCC
Administering ECT to Critically Ill Patients
Rounds in the General Hospital

March 5, 2026

ECT can be lifesaving for critically ill individuals with severe psychiatric and neuropsychiatric conditions; however, cardiac monitoring is essential.
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PCC
Understanding the Impact of Moral Injury
Rounds in the General Hospital

February 26, 2026

Healing of moral injuries requires truth-telling, communal recognition, and moral repair—not just medication or cognitive restructuring.
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Case Reports

PCC
Adjunct Memantine for Inappropriate Sexual Behavior
Case Report

May 14, 2026

Two patients with intellectual disability and major neurocognitive disorder exhibited inappropriate sexual behavior that significantly decreased after memantine was added as adjunctive therapy.
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PCC
From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder
Case Report

May 14, 2026

This case illustrates how hoarding phenomenology can manifest in digital environments, which offer virtually unlimited storage, anonymity, and low visibility.
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PCC
Aripiprazole-Induced Pathological Gambling
Case Report

May 7, 2026

A 27-year-old man with a history of substance abuse developed a new-onset compulsive gambling pattern within weeks of starting aripiprazole.
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PCC
Clozapine-Associated Pulmonary Embolism
Case Report

May 5, 2026

A 48-year-old woman with schizoaffective disorder taking clozapine developed acute pulmonary embolism despite negative D-dimer results.
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PCC
Polydipsia-Related Hyponatremia in Autism
Case Report

April 30, 2026

The authors present the case of a 10-year-old boy with autism who presented to the ED with hyponatremia-related seizures due to compulsive water drinking.
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PCC
Diphenhydramine and Dextromethorphan Overdose
Case Report

April 28, 2026

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.
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Letter to the Editor

PCC
Peer Support to Prevent Suicide Among Medical Students
Letter to the Editor

May 14, 2026

The authors describe a peer support panel discussion designed to address suicide prevention, allowing medical students to actively participate in addressing critical mental health challenges they face in their…
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PCC
Take “Oedipus” Off
Letter to the Editor

May 12, 2026

The authors examine justification for using the name of Oedipus to identify a psychoanalytic concept concerning children aged 3–6 years describing attraction to the parent of the opposite sex…
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PCC
Catatonia, Neurocognitive Disorders, and End-of-Life Care
Letter to the Editor

April 28, 2026

The authors present a combined cohort of 4 patients with baseline neurocognitive disorders who developed catatonia shortly before death.
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PCC
Psychopharmacotherapy Updates
Letter to the Editor

April 7, 2026

The authors provide an update for busy prescribers on the latest FDA-approved psychotropic medications.
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PCC
Psychosis and Kratom
Letter to the Editor

March 10, 2026

The authors discuss the possible association between psychosis and kratom use.
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PCC
CTRA, Stress, and Yoga
Letter to the Editor

February 24, 2026

The authors examine the historical context of stress, the neurobiological mechanisms of conserved transcriptional response to adversity and stress, and how yoga practices counteract its effects.
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More Articles from The Primary Care Companion for DNS Disorders

PCC
Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome
Case Report

April 23, 2026

This case reinforces the importance of monitoring for acute neurologic symptoms in patients treated with high-dose selective serotonin reuptake inhibitors.
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PCC
Osmotic Demyelination Syndrome Presenting as EPS
Case Report

April 21, 2026

A 44-year-old woman was initially referred for presumed domperidone-induced extrapyramidal symptoms, but further workup uncovered a complex interplay of hyponatremia, demyelination, and neuroleptic hypersensitivity.
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PCC
Cultural Manifestations of Bereavement in a Chinese American Patient
Case Report

April 16, 2026

The authors highlight the difficulties of applying western psychiatric concepts to cultural minorities, as seen in a case of complicated bereavement in a 54-year-old Chinese American woman.
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PCC
7-OH-Mitragynine–Induced Psychosis
Case Report

April 14, 2026

The authors present the case of a patient who developed psychosis and delirium following several months of heavy 7-OH use that persisted for nearly a week following cessation.
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PCC
Acitretin, Homocysteine, and Neuropsychiatric Symptoms
Case Report

April 14, 2026

This report describes a case of acitretin-associated hyperhomocysteinemia that induced neuropsychiatric symptoms in a patient with chronic plaque psoriasis, highlighting the need for monitoring.
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PCC
Dose-Dependent Valproic Acid–Induced Hyperkalemia
Case Report

April 9, 2026

The authors present the case of a young man with bradycardia and Jacobs syndrome, in which a clear, dose-dependent relationship between valproic acid and hyperkalemia was observed.
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PCC
Succinylcholine Misuse in a Health Care Worker
Case Report

April 7, 2026

A health care worker with a history of PTSD and substance use misused succinylcholine for stress relief and sleep, highlighting the risks of occupational access to high-risk medications among…
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PCC
Managing FND and Psychiatric Illness
Case Report

April 7, 2026

This case of a 54-year-old woman with schizoaffective disorder illustrates how stigma around psychiatric conditions can impact patient disposition, particularly in patient populations with complex neurological disorders.
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PCC
Bupropion-Dextromethorphan for Clinically Challenging Apathy
Case Report

April 2, 2026

This case shows potential benefits of glutamate system–activating medication in addressing clinically challenging apathy in a 44-year-old man with depression.
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PCC
A Unique Manifestation of Postpartum OCD
Case Report

March 31, 2026

This report explores the case of a woman with postpartum OCD, who exhibited a unique compulsion of taking excessive photos and videos of her surroundings.
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PCC
Mesial Temporal Sclerosis and Juvenile Myoclonic Epilepsy
Case Report

March 26, 2026

The authors present a rare case of coexisting right mesial temporal sclerosis and juvenile myoclonic epilepsy, underscoring the challenges in dual epilepsy syndromes and the importance of individualized, multidisciplinary…
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PCC
Between Crisis and Clarity: Steroid-Induced Psychosis in Addison Disease
Case Report

March 24, 2026

This case highlights a rare but clinically significant dilemma: balancing essential corticosteroid replacement against neuropsychiatric toxicity.
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