Letter to the Editor December 14, 2007

Monocytosis Subsequent to Ziprasidone Treatment: A Possible Side Effect

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Prim Care Companion J Clin Psychiatry 2007;9(6):465-466

Article Abstract

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Sir: Ziprasidone is an atypical antipsychotic agent that is available as oral and short-acting intramuscular formulations and is approved by the U.S. Food and Drug Administration for management of schizophrenia and bipolar disorder. Ziprasidone acts as a serotonin and dopaminereceptor antagonist, with greater affinity for the 5-HT2Areceptor than the dopamine D2 receptor.1 Moreover, it possesses agonist activity at the serotonin 5-HT1A receptor.1