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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Comorbidities Obscure Autism Diagnosis
Case Report

November 25, 2025

A 14-year-old boy with longstanding psychotic illness, posttraumatic stress from adverse social experiences, and suicidality presented for neuropsychiatric assessment.
PCC
Sequelae of Toxic Exposures in Veterans
Rounds in the General Hospital

November 25, 2025

A 45-year-old veteran has ongoing cognitive and physical symptoms likely related to past exposure to burn pits, dust storms, airborne industrial pollutants, poor air quality, multiple blasts, and head…
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PCC
Impact of Patient Suicide on Mental Health Professionals
Original Research

November 20, 2025

Patient suicide can cause lasting emotional and professional distress in mental health professionals due to their unique relationship with the patient.
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PCC
Psychosis or Multiple System Atrophy?
Case Report

November 20, 2025

A 67-year-old woman presented with altered mental status, hallucinations, and hyperalgesia of the bilateral lower legs and was subsequently diagnosed with multiple system atrophy.
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PCC
Religious Preoccupation in Adolescence
Case Report

November 18, 2025

A 16-year-old boy developed new-onset psychosis of religious preoccupation and delusions.
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PCC
Clozapine Withdrawal–Induced Catatonia
Case Report

November 18, 2025

A patient with treatment-resistant schizophrenia developed persistent catatonia after sudden cessation of clozapine, highlighting the challenges in management and the potential role of clozapine reintroduction.
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Figure: Cover highlights articles on psychosis, guilt in physicians, precision psychiatry, medications, and somatic delusions.

Vol 27 • 2025 • Number 5

Read the Current Issue

Original Research

Access to Primary Care in First-Episode Psychosis

Original Research

Cognitive Distortions in Physician Guilt

Narrative Review

Precision Psychiatry for Depression Treatment

Rounds in the General Hospital

Choosing a Pharmacologic Strategy for Psychosis

Rounds in the General Hospital

Managing Somatic Delusions

Case Report

When a Headache Isn’t Just a Headache
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study
Original Research

September 11, 2025

Older adults were found to have less depression and anxiety compared to middle-aged adults; loneliness and perception of knowledge about COVID can affect the association between the presence of…
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PCC
Predictors of Depression Response in a Community ECT Clinic
Original Research

August 28, 2025

Anxiety symptoms may be a factor correlated with depression treatment response, suggesting potential utility in screening for anxiety symptoms in assessing likelihood of success with ECT treatment.
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PCC
Medical Student Reactions to Interviewing Psychiatric Inpatients
Original Research

July 29, 2025

The authors describe a preclinical training program for medical students conducted in a state psychiatric hospital that emphasizes direct contact with patients with serious mental illness.
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Review Articles

PCC
Gender-Affirming Surgery, Gender Dysphoria, and QOL
Review Article

November 11, 2025

Those who receive gender dysphoria treatment at a younger age may experience lower rates of suicidal ideation, underscoring potential mental health benefits of timely intervention.
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PCC
Improving Community Mental Health Care
Narrative Review

October 9, 2025

This review highlights critical areas for enhancing the quality and sustainability of community mental health services.
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PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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PCC
Climate Change and Mental Health
Review Article

July 24, 2025

This scoping review highlights the significant impact of climate change on mental health in India, particularly among individuals from lower socioeconomic backgrounds in rural areas.
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PCC
Efficacy of GLP-1 Agonists in Mental Disorders
Review Article

June 10, 2025

Current evidence underscores the potential of GLP-1 receptor agonists as a novel therapeutic approach for certain psychiatric disorders, particularly AUDs, depression, and autism-related food behaviors.
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PCC
Role of GLP-1 Receptor Agonists in AUD
Narrative Review

May 15, 2025

The authors examine the potential benefits, dosages, and mechanisms of GLP-1 receptor agonists on alcohol consumption and how they can potentially modify alcohol-seeking behavior.
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Rounds in the General Hospital

PCC
Primary Care and Mental Health Collaboration
Rounds in the General Hospital

November 13, 2025

Since PCPs are often the first health care professionals to see patients with symptoms of a mental health disorder, they play a vital role in the identification, management, and…
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PCC
Talking to Pregnant Patients About Substance Use
Rounds in the General Hospital

November 11, 2025

A 33-year-old pregnant woman presented to the obstetric triage unit at 28 weeks. She and her partner reported that this pregnancy was going smoothly except for one thing: she…
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PCC
Talking to Patients About Inflammatory Bowel Diseases
Rounds in the General Hospital

November 6, 2025

Find out what triggers irritable bowel diseases and how your patients can manage their GI symptoms and utilize psychotropic agents in this comprehensive guide.
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PCC
Psychological Sequelae of Drone Attacks
Rounds in the General Hospital

November 6, 2025

Read about a newly emerging form of combat stress, one shaped by the relentless and psychologically corrosive nature of modern drone warfare.
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PCC
Impact of Hypotension on Cognitive Function
Rounds in the General Hospital

October 23, 2025

Hypotension acts synergistically to affect mental status by compounding problems with gas exchange, neurovascular dynamics, neuronal metabolism, and neurotoxicity.
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PCC
Talking to Your Patients About HSCT
Rounds in the General Hospital

September 30, 2025

If you have been unsure about what you should discuss with your patients who might undergo hematopoietic stem cell transplantation, then this case and discussion should prove useful.
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Case Reports

PCC
Lumateperone-Induced Urticarial Rash in Schizophrenia
Case Report

November 13, 2025

This report describes an instance of acute generalized urticaria immediately following an initial dose of lumateperone in a 43-year-old man with schizophrenia.
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PCC
Schizophrenia With Diphenhydramine Abuse
Case Report

November 4, 2025

This report examines the effects of clozapine on diphenhydramine dependence in a 33-year-old patient with schizophrenia.
PCC
Persistent Insomnia in an Elderly Man With HIV
Case Report

October 30, 2025

An 80-year-old man with receiving antiretroviral therapy for HIV since the mid-1990s reported complete inability to sleep, leading to psychological distress and suicidal ideation.
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PCC
Cerebrotendinous Xanthomatosis: Unraveling Prominent Neuropsychiatric Symptoms and MCI
Case Report

October 30, 2025

A 51-year-old woman with an 8-month history of significant cognitive decline and behavioral changes, including forgetfulness, irritability, and anger outbursts, received an initial diagnosis of MCI.
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PCC
Neuropsychiatric Challenges of Friedreich’s Ataxia
Case Report

October 23, 2025

Management of behavioral symptoms in Friedreich’s ataxia patients requires a nuanced approach that integrates psychiatric care with traditional neurological treatment.
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PCC
Fluoxetine-Induced Extrapyramidal Symptoms
Case Report

October 21, 2025

This case highlights the underrecognized risk of extrapyramidal symptoms, particularly drug-induced parkinsonianism, associated with fluoxetine.
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Letter to the Editor

PCC
Brain Injuries, Illness, and Treatment in Sports
Letter to the Editor

October 2, 2025

In their letter to the editor, the authors discuss the need for sports psychiatry and neurology to be viewed as a central part of the sports medicine field.
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PCC
Complicated Grief: Is There a Role for Naltrexone?
Letter to the Editor

September 23, 2025

The authors discuss prolonged grief disorder and the use of medications like naltrexone as a potential treatment.
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PCC
Knowledge of ECT for Catatonia
Letter to the Editor

September 11, 2025

The authors comment on a recent study by Kaur et al assessing what internists and neurologists know about catatonia.
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PCC
Knowledge of Catatonia: Reply to Espinoza and Kellner
Letter to the Editor

September 11, 2025

The authors reply to a letter to the editor commenting on their article.
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PCC
Reversible Cerebral Vasoconstriction Syndrome and Marijuana
Letter to the Editor

July 22, 2025

The authors raise awareness of a potential complication of extensive marijuana use.
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PCC
Onco-Psychopharmacology: Is Mirtazapine a Catholicon?
Letter to the Editor

June 24, 2025

The author discusses the role of mirtazapine in the treatment of depression in patients with cancer.

More Articles from The Primary Care Companion for DNS Disorders

PCC
NMS After Clozapine and ECT
Case Report

October 16, 2025

This case describes the diagnostic challenges of atypical neuroleptic malignant syndrome in a patient with schizophrenia and the potential interaction between clozapine and ECT.
PCC
Trigeminal Neuralgia in MS With OUD
Case Report

October 14, 2025

A 54-year-old woman with MS presented to the ED with a 6-week history of progressively worsening left facial pain. While responsive to opiates, she had a history of OUD.
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PCC
Incubus Syndrome in a Man With Alcohol Dependence
Case Report

October 14, 2025

The authors present a rare case of a 36-year-old man with alcohol dependence who developed multisensory hallucinations characteristic of incubus syndrome.
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PCC
N-Acetylcysteine for Psychogenic Polydipsia
Case Report

October 9, 2025

The authors describe the clinical management of an outpatient with diagnoses of psychogenic polydipsia, schizophrenia, mild intellectual and developmental disability, and autism spectrum disorder.
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PCC
Mosaic Turner Syndrome and Schizophrenia
Case Report

October 7, 2025

This case adds to the literature on Turner syndrome and psychosis and is an example of the heterogeneity of individuals who meet the criteria for treatment-resistant schizophrenia.
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PCC
Valproate-Induced Hypermelanosis
Case Report

September 30, 2025

The authors present 2 cases of hyperpigmentation induced by sodium valproate and valproic acid.
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PCC
Dexamethasone and Cyproheptadine Misuse
Case Report

September 25, 2025

This case provides rare insight into the complications and delayed recognition associated with long-term, nonpsychoactive substance misuse, despite overt harm and a family history of addiction treatment.
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PCC
Neuropsychiatric Symptoms of Morquio Syndrome
Case Report

September 25, 2025

A 70-year-old man with Morquio syndrome presented with mood instability and behavioral changes and became a significant nursing challenge.
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PCC
ECT for Auditory Hallucinations
Case Report

September 23, 2025

A 19-year-old patient with Turner syndrome, schizophrenia and MDD presented for an ECT evaluation after multiple pharmacologic treatments failed to control her refractory auditory hallucinations, which had persisted for…
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PCC
Diagnosing and Treating Dizziness
Rounds in the General Hospital

September 18, 2025

Psychiatric treatment of dizziness includes behavioral therapy to decrease arousal to the identified stimulus and pharmacologic interventions to decrease acute anxiety and prevent onset of downstream anxiety.
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PCC
Imipramine-Induced Catatonia
Case Report

September 18, 2025

The authors present the case of a 15-year-old girl with primary nocturnal enuresis and mild depressive symptoms, who later developed catatonia while on imipramine.
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PCC
Antihistamines: Indications, Interactions, and Adverse Effects
Rounds in the General Hospital

September 16, 2025

Many antihistamines share a propensity for muscarinic receptor antagonism at higher doses, leading to symptoms of anticholinergic toxicity.
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Expert Consensus on Aripiprazole LAIs in Clinical Practice

Read the full report
Figure. Image of a syringe on two vials highlights aripiprazole monohydrate LAI clinical use in Bipolar I Disorder.

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